Clinical Research Associate II

Piper Companies; United States; Remote; USD 100,000 - 130,000; Full time

Job summary

Piper Companies is seeking a Clinical Research Associate II for a remote permanent role that travels 60-75% across the United States to support cardiovascular, CNS, and metabolic studies. The CRA II will partner with investigative sites to ensure high-quality trial execution.

Responsibilities include monitoring visits, ensuring compliance with GCP/ICH and FDA regulations, reviewing data and source documents, and training site staff on protocol requirements. A bachelor’s degree is required.

Qualifications

• 1–4 years of onsite clinical monitoring experience.
• Experience in cardiovascular, CNS, or metabolic trials.
• Strong knowledge of GCP, ICH, and FDA regulations.

Responsibilities

• Perform routine and close-out monitoring visits to ensure alignment with GCP/ICH/FDA.
• Serve as primary contact for assigned sites and maintain ongoing communication.
• Review site data, source documents, and regulatory files for accuracy.
• Provide guidance and training to site staff on protocol requirements.
• Identify, document, and escalate deviations or issues.

Skills

Site monitoring

GCP/ICH/FDA knowledge

Regulatory compliance

Education

Bachelor’s degree in life sciences, nursing, or related field

Tools

CTMS

EDC systems

Job description

Piper Companies is seeking a Clinical Research Associate II to join a global organization within the clinical research and life sciences industry for a remote permanent role with 60-75% travel across the United States. This CRA II will support cardiovascular, CNS, and metabolic studies while partnering closely with investigative sites to ensure high-quality trial execution.

Responsibilities of the Clinical Research Associate II include:

• Perform routine and close-out monitoring visits to ensure studies are conducted in alignment with GCP, ICH, and applicable regulations.
• Serve as the primary point of contact for assigned research sites, fostering strong relationships and ongoing communication.
• Review site data, source documentation, and regulatory files to confirm accuracy, completeness, and protocol adherence.
• Provide guidance and training to site staff on protocol requirements, study procedures, and compliance expectations.
• Identify, document, and esc…

Qualifications for the Clinical Research Associate II include:

• 1–4 years of onsite clinical monitoring experience, aligned to CRA II or Senior CRA I level.
• Experience supporting clinical trials within cardiovascular, CNS, diabetes, or metabolic indications.
• Strong working knowledge of GCP, ICH guidelines, and FDA regulatory requirements.
• Proficiency with CTMS, EDC systems, and standard clinical trial documentation.
• Bachelor’s degree in life sciences, nursing, or a related discipline; Spanish fluency is highly preferred for candidates based in Florida or Puerto Rico.

Compensation for the Clinical Research Associate II:

Salary Range: $100,000–$130,000/year (USD)

Comprehensive Benefits: Medical, Dental, Vision, sick leave if required by law, and 401(k)

This job opens for applications on 10/30/26. Applications for this job will be accepted for at least 30 days from the posting date.

Keywords: clinical research, clinical trials, CRA, GCP, ICH, regulatory compliance, site monitoring, clinical monitoring, CTMS, EDC, cardiovascular studies, CNS trials, diabetes research, GLP-1, site management, FDA regulations, clinical operations, documentation, quality assurance, protocol compliance, investigator sites, patient safety, clinical development.