Senior Clinical Research Associate

Piper Companies; Columbus (OH); On-site; USD 120,000 - 145,000; Full time

Job summary

Piper Companies seeks an experienced Senior Clinical Research Associate to support Phase II–III Oncology trials in a sponsor-facing role. This full-time position requires regional travel and is primarily in the West, Mountain, and Central time zones.

You will monitor sites, conduct initiation, routine monitoring and closeouts, perform SDR/SDV/CRF reviews, and collaborate with sponsors to meet enrollment goals and maintain data quality.

Qualifications

• 4+ years of CRA experience with oncology trials.
• Strong knowledge of ICH-GCP, FDA regulations and regulatory requirements.
• Experience supporting Phase II/III studies with site oversight and issue resolution.
• Ability to manage multiple sites with minimal supervision.
• Excellent sponsor-facing communication skills.

Responsibilities

• Independently monitor Phase II–III oncology trials to ensure protocol and regulatory compliance.
• Conduct site initiation, routine monitoring, and closeout visits with high oversight of sites.
• Perform SDR/SDV and CRF review to ensure accurate, inspection-ready data.
• Build strong partnerships with investigative sites to support enrollment and protocol adherence.
• Collaborate with sponsors, study teams, and site personnel; provide regular updates on site performance.

Skills

Clinical Research Associate

Site monitoring

GCP compliance

FDA regulations

Oncology trials

Sponsor-facing communication

Job description

Piper Companies is seeking an experienced Senior Clinical Research Associate (CRA) to support Phase II–III Oncology clinical studies in a dynamic, sponsor-facing environment. This role will be responsible for overseeing site performance, ensuring regulatory compliance, and driving successful trial execution through strong site relationships and hands-on monitoring activities. This is a full time opportunity that requires regional travel and is primarily in the West, Mountain, and Central times.

Responsibilities for the Senior Clinical Research Associate include:

• Independently monitoring Phase II–III Oncology clinical trials to ensure compliance with study protocols, ICH-GCP guidelines, and regulatory requirements.
• Conducting site initiation, routine monitoring, and closeout visits while maintaining high-quality oversight of investigative sites.
• Performing source data review (SDR), source data verification (SDV), and case report form (CRF) review to ensure accurate and inspection-ready study data.
• Building strong partnerships with investigative sites to support enrollment goals, protocol adherence, and overall study success.
• Collaborating directly with sponsors, study teams, and site personnel while providing regular updates on site performance and trial progress.

Qualifications for the Senior Clinical Research Associate include:

• 4+ years of Clinical Research Associate experience, including significant experience independently monitoring Oncology clinical trials.
• Strong knowledge of ICH-GCP guidelines, FDA regulations, clinical trial operations, and site management best practices.
• Experience supporting Phase II and Phase III studies with responsibility for site oversight, monitoring, and issue resolution.
• Proven ability to conduct site initiation, interim monitoring, and closeout visits independently.
• Strong sponsor-facing communication skills and experience working directly with biotechnology or pharmaceutical clients.
• Ability to manage multiple investigative sites, prioritize competing demands, and work effectively with minimal supervision.
• Must be located within reasonable distance of a major airport and willing to travel regionally as required.

Compensation for the Senior Clinical Research Associate includes:

• Salary range: $120,000 - $145,000
• Comprehensive benefits package including Medical, Dental, Vision, 401k, PTO, holidays, and sick leave as required by law.

Keywords: Senior Clinical Research Associate, Senior CRA, Clinical Research Associate, Oncology Clinical Trials, Oncology Research, Phase II Clinical Trials, Phase III Clinical Trials, Clinical Monitoring, Independent Monitoring, Site Monitoring, Site Management, Clinical Operations, ICH-GCP, FDA Regulations, GCP Compliance, Clinical Trial Management, Source Data Verification, SDV, Source Data Review, SDR, CRF Review, Case Report Forms, Site Initiation Visits, SIV, Interim Monitoring Visits, IMV, Closeout Visits, COV, Investigative Sites, Study Start-Up, Patient Enrollment, Site Performance, Risk Management, Protocol Compliance, Clinical Development, Biotechnology, Biotech Sponsor, Pharmaceutical Research, CRO, Sponsor-Facing, Trial Execution, Site Oversight, Data Quality, Inspection Readiness, Regulatory Compliance, Oncology Studies, Clinical Research, Clinical Trial Oversight, Clinical Monitoring Visits, Site Relationships, Clinical Study Management.

This job is open for applications on 10/30/2026 and will remain open for at least 30 days from the posting date