Clinical Pharmacologist - PK/PD Expert

Obsidian; New York (NY); On-site; USD 83,000 - 124,000; Part time

Job summary

Obsidian is seeking a clinical pharmacologist to own pharmacology data generation and dose justification across PK/PD workflows for our early‑phase programs. You will also author dose selection rationale, drug concentration sections, and interaction content, while designing prompts and rubrics to validate AI outputs.

Location: US/Canada/France flexibility; 20–25 hours weekly, with 30+ preferred. Must have supported pre-market programs (Phases 1–3) and hands‑on PK/PD experience; first‑in‑human

Qualifications

• Must have supported pre-market (Phases 1–3) programs as a clinical pharmacologist.
• Hands-on PK/PD work with dose selection and escalation.
• Experience with exposure–response analysis.
• First‑in‑human experience strongly preferred.
• Able to work from protocol and SAP to produce pharmacology data for expert scrutiny.

Responsibilities

• Own the pharmacology data generation across multiple workflows.
• Author dose selection rationale and content for reports and prompts.
• Design prompts, rubrics, and golden outputs to evaluate AI agents.
• Collaborate with cross-functional teams to ensure clinical plausibility.

Skills

PK/PD analysis

Clinical data generation

Dose selection

Dosing regimens design

Interdisciplinary collaboration

Education

PharmD

PhD in pharmacology

MD or equivalent

Job description

As a clinical pharmacologist on this project, you would own a part in multiple workflows:

1. Clinical Data Generation: we need to simulate the pharmacology layer of each data room, including PK and PD datasets, dosing and escalation regimens, exposure-response relationships, and bioanalytical reports, so that dose rationale and concentration data are clinically plausible and reconcile against the efficacy and safety outputs.

2. Clinical pharmacology task authorship: you must be capable of authoring the dose selection rationale, drug concentration and response sections, and drug-drug and drug-disease interaction content, and designing prompts, golden outputs, and rubrics to quantify the ability of an AI agent attempting to do the same thing.

To be qualified for this role, you must fit the following requirements:

• Location: US, Canada, or France.

• YOE: 5+ required. 10-25 preferred.

• Education: PharmD, PhD in pharmacology, pharmacokinetics or a related field, MD, or equivalent.

• Hourly availability: 20-25 hours/week, minimum. 30+ preferred.

• Experience: MUST have supported pre-market (Phases 1-3) programs as a clinical pharmacologist, with hands‑on PK/PD work, dose selection and escalation, and exposure‑response analysis. First‑in‑human experience strongly preferred. Comfortable working from a protocol and SAP to produce pharmacology data that holds up under expert scrutiny.