Clinical Laboratory Scientist II

Natera; Boulder (CO); On-site; USD 70,000 - 100,000; Full time

Job summary

Foresight Diagnostics, now part of Natera, is seeking a Clinical Laboratory Scientist II in Boulder, CO, to perform end-to-end processing for NGS-based cancer detection workflows. You will lead pre-analytical and analytical activities, ensuring high-quality results while participating in process improvements.

The ideal candidate holds a CLS license, ASCP certification, and a strong foundation in PCR/qPCR, DNA extraction, and related molecular techniques.

Qualifications

• Bachelor’s or Master’s degree in chemical, physical, biological, or clinical laboratory science or medical technology from an accredited institution.
• Education from outside the United States requires a credentials equivalency evaluation by an approved agency.
• Hold a current ASCP board certification.
• Hold active Clinical Laboratory Scientist licensure (Generalist or CGMBS).
• Demonstrate working knowledge of DNA biology and molecular biology techniques.

Responsibilities

• Perform routine and complex diagnostic laboratory testing on patient samples for clinical, biopharma, and academic partnerships.
• Provide technical guidance to non-licensed personnel for pre-analytical, analytical and post-analytical activities.
• Interpret data according to procedures and guidelines and ensure quality results.
• Support operations with data entry, sample reception, reagent prep, and documentation.

Skills

Molecular biology

DNA biology

Lab safety

Technical troubleshooting

Team collaboration

Education

Bachelor’s or Master's in chemical, physical, biological, or clinical laboratory science or medical technology

US credentials equivalency evaluation for degrees earned outside US

Tools

Agilent Tapestation

Capillary electrophoresis

Qubit

Plate readers

Therocyclers / PCR machines

Job description

About our Company:

Foresight Diagnostics is a molecular diagnostics company pioneering non-invasive cancer detection through highly sensitive, cell-free DNA-based liquid biopsy technologies. Our proprietary methods - originally developed at Stanford University - are designed to detect smaller tumors earlier and enable more personalized treatment strategies for patients with cancer.

We sit at the intersection of molecular biology, bioinformatics, and next-generation sequencing (NGS), and we translate rigorous science into clinically meaningful solutions. Following our acquisition by Natera, we now combine the agility of a mission-driven startup with the scale and resources of a global leader in cell-free DNA testing. It’s an exciting moment to join us.

Headquartered in Boulder, Colorado, our team operates in a high accountability, collaborative environment where quality and continuous improvement aren’t just values - they’re how we work every day.

About the Role

The Clinical Laboratory Scientist II will be responsible for performing a variety of laboratory procedures involved in end-to-end processing of biological samples to enable successful downstream next-generation sequencing (NGS). Processing will include accessioning and both manual and automated extraction, library preparation, hybrid capture, sequencing and QC steps. Under the guidance of the Director of Clinical Laboratory Operations and the Laboratory Director, you will work collaboratively within the clinical laboratory leveraging your technical knowledge, skills and abilities to ensure efficient and quality results are provided to our clients and patients while also informing/participating in process improvements. This position will report to the Lab Manager.

What You Will Bring

Bachelor’s or Master's degree in chemical, physical, biological, or clinical laboratory science or medical technology from an accredited institution

Education received at a college or university located outside of the United States or United States Territories requires a credentials equivalency evaluation by an approved agency

Hold a current and active American Society of Clinical Pathology (ASCP) board certification

Hold current and valid Clinical Laboratory Scientist licensure (Generalist or CGMBS)

Demonstrate a working knowledge of the general biological principles that govern DNA biology

Possess a strong foundational understanding of common molecular biology techniques, such as PCR/qPCR, DNA ligation, and DNA extraction

Working level knowledge or ability to learn use of common molecular biology instruments; Agilent Tapestation/capillary electrophoresis, Qubit, plate readers, thermocyclers and other common laboratory instruments

Previous experience handling human biological materials is required

Working knowledge of how to safely operate in a BSL-2 environment is required

Previous experience handling, processing, and extracting DNA from biological specimens is required

What You Will Do

Technical

Perform routine and complex diagnostic laboratory testing on patient samples for clinical, biopharma, and academic partnerships.

Provide technical guidance and oversight to non-licensed personnel for pre-analytical, analytical and post-analytical activities.

Interpret data and results of all analyses according to set procedures and guidelines.

Support day to day operations by assisting with data entry, receiving samples and consumables, reagent preparation, sample preparation, temperature recording, laboratory maintenance and documentation.

Identify and resolve problems that may adversely affect test performance or reporting of test results following the escalation path to clinical leadership as needed.

Assist with research, translational research, regulated products through the execution of partnership studies and internal/external validation studies.

Participate as a