Chief of Staff

Weave Bio; San Francisco (CA); Hybrid; USD 170,000 - 200,000; Full time

Benefits offered by this job

Hybrid in SF (Tue/Wed/Thu in-office)

Competitive salary

Equity package

Health, dental, vision insurance

PTO & parental leave

OneMedical & TalkSpace access

Career development opportunities

Job summary

Weave is seeking a Chief of Staff to the CEO to own the operating system and lead high-impact projects. You will turn ambiguous priorities into concrete plans, run KPI reporting, and ensure execution across Product, Engineering, Customer Success, Sales, and Marketing.

You will also drive AI-enabled improvements while maintaining focus on strategic objectives. The role requires a track record of cross-functional leadership, data-driven decision making, and exceptional communication.

Qualifications

• 7–10 years of professional experience with a Bachelor's degree, or 5–7 years with an MBA.
• Experience operating in a B2B SaaS environment, ideally at a startup or high-growth company.
• Track record turning ambiguities into executable plans and measurable outcomes.
• History of leading cross-functional projects with executives.
• Exceptional organizational skills and operational discipline.
• Strong business judgment and influence without formal authority.
• Excellent written and verbal communication skills.
• Analytical and problem-solving mindset; data-driven decisions.
• Bias toward action and willingness to dive into detail when needed.

Responsibilities

• Drive execution on company priorities by turning ambiguous priorities into clear plans with milestones and owners.
• Build and run Weave's operating system, including planning, KPI reporting, and scalable processes.
• Lead special projects from concept through execution with cross-functional collaboration.
• Creatively and effectively employ AI to increase capacity and velocity without derailing objectives.
• Increase leadership leverage by preparing executives with structured options for key decisions.

Skills

Cross-functional leadership

Strategic planning

Data-driven decisions

Executive communication

Project management

AI deployment understanding

Operational discipline

Education

Bachelor's degree

MBA

Tools

SQL

Excel

PM tools

Job description

Why Weave Exists

At Weave, our mission is to evolve how therapeutic knowledge is captured, transformed, and communicated throughout drug development. We do this by equipping human experts with AI instruments to enable drugs to be brought to patients as rapidly, safely, and inexpensively as possible.

Why Weave Exists

At Weave, our mission is to evolve how therapeutic knowledge is captured, transformed, and communicated throughout drug development. We do this by equipping human experts with AI instruments to enable drugs to be brought to patients as rapidly, safely, and inexpensively as possible.

The Weave Platform streamlines regulatory workflows from start to finish by intelligently, creatively, and effectively infusing every step with AI. Together with our customers, Weave is designing and building the AI workbench for the entire therapeutic lifecycle.

About the Role

Weave is looking for a Chief of Staff to the CEO. This role has two primary remits:

The first is ownership of Weave's "operating system". Building and running the necessary structures, processes, and buy‑in to ensure Weave's business runs on data. Clarity of purpose, alignment to company objectives, decision-empowerment, and timely measurement are the key priorities. Data will need to be drawn from many systems and every function, so analytical and technical savvy, and an ability to collaborate effectively are essential.

The second is high-impact special projects. No two will be the same, none will come with a playbook, most will be primarily business/operational in nature. Their success will depend on the ability to rapidly understand the need and goal, define success, formulate a practical plan, and execute to conclusion. These will involve Weave's leadership team and occasionally customers or partners.

This role is high leverage and low specification. It is an exceptional opportunity to use analytical wherewithal, creativity, and grit to generate a high impact on a transformative business.

What You’ll Do

• Drive execution on company priorities. Turn ambiguous priorities into clear plans, milestones, owners, and next steps. Identify dependencies, surface risks, and remove roadblocks across Product, Engineering, Customer Success, Sales, and Marketing—knowing when to escalation to leadership and when to drive the work yourself.
• Build and run Weave's operating system. Establish the company's operating cadence, run effective leadership meetings (agendas, prep, follow-through), and maintain visibility into priorities, owners, and milestones. Own company‑level planning, goal‑setting, and KPI reporting, and design scalable processes for recurring operational problems.
• Lead special projects. Take on high‑impact, cross‑functional initiatives—operational, compliance, or organizational—from concept through execution. Coordinate external partners and vendors as needed, and continuously look for ways to make the organization more efficient.
• Creatively and effectively employ AI. This role will be a central player in effective deployment of AI across Weave's business operations. AI is an essential tool for success in this role and must be employed with an understanding of its strengths and limitations. It is expected to increase capacity and velocity significantly, but its use cannot impede the ultimate achievement of the necessary business objectives.
• Increase leadership's leverage. Prepare executive leadership for key decisions by gathering context and structuring options, so they can stay focused on the company's highest‑value priorities, customers, and board relationships.

What You’ll Bring

• 7–10 years of professional experience with a Bachelor's degree, or 5–7 years of experience with an MBA.
• Experience operating in a B2B SaaS environment, ideally at a startup or high‑growth company.
• A demonstrated track record of taking ambiguous problems and turning them into executable plans and measurable outcomes.
• History of leading cross‑functional projects in collaboration with functional leaders and executives.
• Exceptional organizational skills and operational discipline.
• Strong business judgement and ability to influence and drive outcomes without relying on formal authority.
• Excellent written and verbal communication skills.
• Strong analytical and problem‑solving skills; you naturally seek data and evidence when making decisions.
• A bias toward action and a willingness to get into the details when necessary.

What We Offer

• The opportunity to work at a modern, cutting‑edge healthcare technology company devoted to meaningful positive impact on human life. Collaboration, velocity, and customer obsession are our baseline, demonstrations of craftsmanship and ROI are celebrated.
• Competitive salary ($170,000 - $200,000), participation in the company bonus plan and equity packages.
• Comprehensive health, dental and vision insurance
• Take care of you and yours: generous PTO, parental leave, OneMedical, TalkSpace, Teladoc.
• Career development opportunities within a company entering a growth phase.
• Hybrid in San Francisco with in-office days Tues/Wed/Thurs and flexibility to work remote Mon/Fri.

Equal Opportunity Employer: We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

This organization participates in e-Verify:

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