CART Manufacturing Process Scientist

Pioneer Data Systems; South San Francisco (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

SmartRecruiters, Inc. seeks a Scientist to drive development and characterization of clinical-scale CART manufacturing processes in San Francisco.

The role emphasizes advancing GMP-ready methods, tech transfer to CMOs, and close collaboration with CART R&D and regulatory teams. The successful candidate will design experiments, optimize transfection, cell engineering, and culture workflows, and ensure rigorous documentation for potential regulatory submissions.

Qualifications

• BS or MS degree in Molecular Immunology/Molecular Biology, Bioengineering, or related degree (with appropriate cell and gene therapy focus) with 3+ years of biotech/biopharma experience.
• Experience in development and characterization of manufacturing processes for cell- or gene-based therapies.
• Knowledge of regulatory expectations and cGMP principles.

Responsibilities

• Develop and implement robust CART manufacturing processes for clinical-scale production.
• Support tech transfer to CMO and GMP manufacturing.
• Contribute to innovations in transfection, cell engineering, media development, and closed production systems.
• Collaborate with CART R&D groups and stakeholders to ensure project alignment.
• Maintain high-quality documentation and contribute to regulatory filings as needed.
• Present data and strategy in internal meetings and cross-functional teams.

Skills

Process development

T-cell culture

Aseptic technique

T-cell activation

Viral transduction

mRNA electroporation

cGMP knowledge

Single-use bioprocessing

Design of Experiments

Education

BS or MS in Molecular Immunology/Molecular Biology/Bioengineering

Tools

WAVE bioreactors

CliniMACS Prodigy

Job description

SmartRecruiters, Inc. seeks a Scientist to drive development and characterization of clinical-scale CART manufacturing processes in San Francisco.

The role emphasizes advancing GMP-ready methods, tech transfer to CMOs, and close collaboration with CART R&D and regulatory teams. The successful candidate will design experiments, optimize transfection, cell engineering, and culture workflows, and ensure rigorous documentation for potential regulatory submissions.