Bench Scientist II

Mindlance; South San Francisco (CA); On-site; USD 80,000 - 100,000; Full time

Job summary

A national recruiting firm is seeking a results-oriented individual for a role focused on the development and characterization of CART therapy manufacturing processes. This position requires analytical support for GMP manufacturing operations and strong expertise in cell biology, particularly with T cells. Candidates should have a B.S. with 3+ years or an M.S. with 2+ years in cellular biology, alongside advanced analytical skills. Strong collaboration and communication abilities are essential for success in this dynamic team.

Qualifications

• B.S. +3 years or M.S. + 2 years in cellular biology or biological sciences is preferred.
• Demonstrated advanced analytical and troubleshooting skills required.
• Industry laboratory experience in analytical methods for characterization of cell-based therapies is necessary.

Responsibilities

• Provide analytical support for clinical-scale non-GMP/GMP manufacturing operations.
• Contribute to development and qualification of analytical methods for CART processes.
• Collaborate to enhance product characterization and identify critical cellular quality attributes.
• Ensure timely documentation in electronic laboratory notebooks.
• Regularly present data to scientists and management.

Skills

Multicolor flow cytometry (FACS)

Immunology and T cells knowledge

Cell biology capabilities

Biomarker experience

Education

B.S. in cellular biology or biological sciences

M.S. in cellular biology or related field

Job description

Mindlance is a national recruiting company which partners with many of the leading employers across the country. Feel free to check us out at http://www.mindlance.com.

Job Description

Summary:

We are seeking a results-oriented, self-starter who demonstrates personal accountability for outcomes and thrives on increasing levels of responsibility, to join a new and dynamic team responsible for successful development and characterization of clinical-scale manufacturing processes for Chimeric Antigen Receptor T cell (CART) therapies. The successful candidate will help to develop and qualify analytical methods for the characterization, release and stability testing of CART products. In particular, this position will be responsible for the generation, integration, analysis, and interpretation of multi-parametric flow cytometry data, and other associated technologies, using bulk- and single-cell technologies. He/ she will collaborate with team members and key stakeholders, including the CART Process and R&D groups.

Job Description:

• Provide analytical support for clinical-scale non‑GMP/GMP IND-enabling manufacturing operations, including qualification of in-process and release methods, and tech transfer internally and externally, in support of manufacturing and release of clinical material.
• Actively contribute to successful development, qualification and execution of robust, state-of-the-art analytical methods for characterization of CART manufacturing processes and products.
• Collaborate productively to understand process/ product relationships, enhance product characterization, and help identify critical cellular quality attributes.
• Establish strong personal accountability, demonstrate good interpersonal skills, communicate and collaborate effectively with leadership and peers to ensure productive interactions, and contribute to project technical teams to ensure effective integration at all levels.
• Apply good organizational skills, and sound scientific and technical experience to establish high-quality lab practices in order to maintain consistent and accurate test data.
• Ensure timely documentation in electronic laboratory notebooks, and author/ contribute to technical reports related to regulatory filings/responses as appropriate.
• Regularly present data/ strategy to scientists and management, in internal and external venues, as well as publish in peer-reviewed journals, as appropriate.

Technical skills:

• Extensive multicoloar flow cytometry (FACS)
• Immunology and T cells knowledges.
• Cell biology capability – cryopreservation, cell culture, cytotoxicity, cytokine, proliferation
• Biomarker experience is a plus.

Minimum education experience required:

• B.S. +3 years or M.S. + 2 years in cellular biology, biological sciences discipline is preferred preferably in cell-scale studies, along with demonstrated advanced analytical and troubleshooting skills.
• Industry laboratory experience in a variety of analytical methods for the characterization and GMP release of cell-based or gene-related therapies, especially flow cytometry-related immunophenotyping.
• Applied skills in cell biology, particularly in primary T cell culture/expansion and immunologic characterization.

Qualifications

Minimum education experience required:

• B.S. +3 years or M.S. + 2 years in cellular biology, biological sciences discipline is preferred preferably in cell-scale studies, along with demonstrated advanced analytical and troubleshooting skills.
• Industry laboratory experience in a variety of analytical methods for the characterization and GMP release of cell-based or gene-related therapies, especially flow cytometry-related immunophenotyping.
• Applied skills in cell biology, particularly in primary T cell culture/expansion and immunologic characterization.

Additional Information

All your information will be kept confidential according to EEO guidelines.