CAR‑T Process Development Scientist (Contract)

Allogene Therapeutics; South San Francisco (CA); On-site; USD 62,000 - 69,000; Full time

Benefits offered by this job

Annual bonus

Equity

Health insurance

Generous time off

Job summary

Allogene Therapeutics in South San Francisco seeks a Senior Associate Scientist to develop and characterize clinical-scale CART manufacturing processes, supporting robust tech transfer for GMP manufacturing. You will contribute to state-of-the-art processing technologies and evaluate new approaches to meet future CART manufacturing needs.

Key tasks include designing and executing DoE studies, optimizing process parameters, documenting results, and collaborating with cross-functional teams.

Qualifications

• BS in Chemical Engineering, Biochemistry, Molecular & Cell Biology, or Immunology or related degree.
• MS plus at least 2 years experience or BS with at least 5 years experience.
• Foundational understanding of mammalian or primary cell culture, biochemistry, molecular & cell biology and immunology.
• Experience with gene therapy manufacturing preferred, but not required.
• Experience in flow cytometry required (T cells characterization preferred).
• Ability to work in a fast-paced, startup environment.
• Authorized to work in the U.S.
• This is a 1-year contract opportunity with the possibility of extension or contract-to-hire.

Responsibilities

• Actively contribute to development, implementation and robust CART manufacturing processes.
• Execute and analyze DoE studies to support process understanding, optimization, and characterization activities.
• Support clinical-scale non-GMP manufacturing operations for execution of BLA-enabling process characterization activities.
• Support and contribute to process characterization efforts and continuous improvement initiatives aimed at enhancing CART manufacturing processes and capabilities.
• Contribute to Project Technical Teams and communicate with all stakeholders.
• Ensure high-quality documentation in ELNs and Technical Reports and contribute to regulatory filings as appropriate.
• Present data/strategy to scientists and management in internal venues.
• Remain current with relevant cell therapy, immunology, and bioprocessing literature.

Skills

Flow cytometry

Mammalian cell culture

Biochemistry

Molecular biology

DoE

Education

Bachelor's degree in Chemical Engineering, Biochemistry, Molecular & Cell Biology, or Immunology

MS preferred or BS with 5+ years experience

Tools

Bioprocessing equipment

Cryopreservation

Gene delivery technologies

Upstream bioreactor/WAVE expansion

Job description

Allogene Therapeutics in South San Francisco seeks a Senior Associate Scientist to develop and characterize clinical-scale CART manufacturing processes, supporting robust tech transfer for GMP manufacturing. You will contribute to state-of-the-art processing technologies and evaluate new approaches to meet future CART manufacturing needs.

Key tasks include designing and executing DoE studies, optimizing process parameters, documenting results, and collaborating with cross-functional teams.