Biotherapeutics Expression Scientist - CHO & Multispecifics

BioSpace; North Chicago (IL); On-site; USD 110,000 - 160,000; Full time

Job summary

AbbVie Biotherapeutics and Genetic Medicine in the United States is seeking an experienced protein expression scientist to join a fast-paced, high-throughput CHO cell culture group. The role focuses on engineering biologics, protein expression, and characterization, with emphasis on data digitization and automation.

You will lead experiments from design to interpretation, perform stable CHO cell work, and contribute to process development for fed-batch bioreactors, aiming to advance therapeutic

Qualifications

• Bachelor's or Master's in biology, chemistry, biochemistry or related field.
• 5+ (BS) or 2+ (MS) years of experience in cell culture and protein production in CHO cells.
• Process development and optimization experience in CHO cells.
• Experience with targeted integration, FACS, ddPCR, vector design, and Wave bioreactors is desirable.
• Strong problem-solving and communication skills.

Responsibilities

• Generation, expression, and screening of stable CHO cell lines expressing multispecific biologics.
• Process development and optimization for fed-batch bioreactor and shake flask expressions.
• Handling stable CHO pool cell lines including thaw, culture, expression and cryopreservation.
• Apply targeted integration using FACS-based single-cell sorting for screening.
• Characterization of copy number and mRNA transcript levels using ddPCR and related tools.
• Implement and leverage automation platforms and high-throughput workflows to increase efficiency.
• Contribute to data digitization efforts, including electronic data capture and reporting.
• Work independently on design, execution, and interpretation of experiments.

Skills

Cell culture

Protein production

Team collaboration

Science communication

Education

Bachelor's or Master's in Life Sciences

Tools

FACS

ddPCR

Wave bioreactors

Job description

AbbVie Biotherapeutics and Genetic Medicine in the United States is seeking an experienced protein expression scientist to join a fast-paced, high-throughput CHO cell culture group. The role focuses on engineering biologics, protein expression, and characterization, with emphasis on data digitization and automation.

You will lead experiments from design to interpretation, perform stable CHO cell work, and contribute to process development for fed-batch bioreactors, aiming to advance therapeutic