Bioorganic Synthesis Scientist - LC-MS/MS & Proteomics

Dayhoff Labs; Cambridge (MA); Presencial; USD 120.000 - 180.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Visa sponsorship

Competitive compensation

Descripción de la vacante

Dayhoff Labs in Cambridge, MA seeks a chemist who blends organic synthesis with analytical expertise to synthesize biological molecules and develop methods to study their behavior in chemical and biochemical reactions.

You'll design syntheses, develop LC-MS/MS methods, apply Orbitrap proteomics, and collaborate with enzymologists and computational scientists to interpret results and build reproducible workflows.

Formación

• Practical experience in organic synthesis of biological molecules, particularly peptides and/or nucleic acid derivatives.
• Strong analytical method development skills, including sample preparation, chromatographic separation, and quantitative mass spectrometry.
• Hands-on experience with triple-quadrupole LC-MS/MS and Orbitrap-based proteomics.
• The ability to independently troubleshoot synthetic and analytical problems, from poor reaction yields to ambiguous spectra or matrix effects.
• Sound scientific judgement about experimental design, data quality, and what your measurements can support.

Responsabilidades

• Design and execute syntheses of biological molecules and their derivatives, optimising reaction conditions and purification strategies.
• Develop and troubleshoot LC-MS/MS methods, particularly triple-quadrupole methods for targeted quantification of substrates and products.
• Apply Orbitrap-based proteomics workflows to characterise peptides, proteins, and their modifications.
• Establish compound identity and purity using chromatography, NMR, and mass spectrometry.
• Work with experimental and computational colleagues to design assays, test proposed chemistry, and investigate unexpected results.
• Build reproducible synthetic and analytical workflows, with appropriate controls, calibration, and clear documentation.

Conocimientos

Organic synthesis

LC-MS/MS

Orbitrap proteomics

NMR

Chromatography

Mass spectrometry

Analytical method development

Troubleshooting

Experimental design

Herramientas

Triple-quadrupole LC-MS/MS

Orbitrap instruments

Descripción del empleo

Dayhoff Labs in Cambridge, MA seeks a chemist who blends organic synthesis with analytical expertise to synthesize biological molecules and develop methods to study their behavior in chemical and biochemical reactions.

You'll design syntheses, develop LC-MS/MS methods, apply Orbitrap proteomics, and collaborate with enzymologists and computational scientists to interpret results and build reproducible workflows.