Biomolecule Synthesis & LC-MS Research Scientist

Bazeta; Cambridge (MA); On-site; USD 150,000 - 210,000; Full time

Benefits offered by this job

Visa sponsorship

Job summary

Dayhoff Labs in Cambridge, MA is seeking a Research Scientist to design and execute syntheses of biological molecules, optimise reaction conditions, and develop quantitative LC-MS/MS methods for complex biochemical analyses. You will collaborate with enzymology and computational teams to interpret results and advance synthetic biology workflows.

The role emphasises hands-on organic synthesis, peptides and nucleic acid derivatives, coupled with advanced mass spectrometry and chromatography to

Qualifications

• Practical experience in organic synthesis of biological molecules, particularly peptides and/or nucleic acid derivatives.
• Strong analytical method development skills, including sample preparation, chromatographic separation, and quantitative mass spectrometry.
• Hands-on experience with triple-quadrupole LC-MS/MS and Orbitrap-based proteomics.
• The ability to independently troubleshoot synthetic and analytical problems, from poor reaction yields to ambiguous spectra or matrix effects.
• Sound scientific judgement about experimental design, data quality, and what your measurements can support.

Responsibilities

• Design and execute syntheses of biological molecules and their derivatives, optimising reaction conditions and purification strategies.
• Develop and troubleshoot LC-MS/MS methods, particularly triple-quadrupole methods for targeted quantification of substrates and products.
• Apply Orbitrap-based proteomics workflows to characterise peptides, proteins, and their modifications.
• Establish compound identity and purity using chromatography, NMR, and mass spectrometry.
• Work with experimental and computational colleagues to design assays, test proposed chemistry, and investigate unexpected results.
• Build reproducible synthetic and analytical workflows, with appropriate controls, calibration, and clear documentation.

Skills

Organic synthesis of biomolecules

Analytical method development

LC-MS/MS proteomics

Troubleshooting experiments

Scientific judgment

Tools

LC-MS/MS

Orbitrap proteomics

NMR

Chromatography

Job description

Dayhoff Labs in Cambridge, MA is seeking a Research Scientist to design and execute syntheses of biological molecules, optimise reaction conditions, and develop quantitative LC-MS/MS methods for complex biochemical analyses. You will collaborate with enzymology and computational teams to interpret results and advance synthetic biology workflows.

The role emphasises hands-on organic synthesis, peptides and nucleic acid derivatives, coupled with advanced mass spectrometry and chromatography to