Biologics Characterization Scientist - LC-MS & Biophysics

Takeda; Lexington (MA); On-site; USD 116,000 - 182,000; Full time

Job summary

Takeda is seeking a Scientist, Biologics Characterization in Lexington, MA to independently plan, execute, and report characterization studies supporting CMC, comparability, and regulatory submissions.

You will use mass spectrometry, biophysical methods, and LC‑UPLC separations, developing strategies and mentoring teammates while collaborating with cross‑functional partners. This role emphasizes data quality and scientific rigor.

Qualifications

• Bachelor’s degree or higher with significant experience in analytical development or biologics characterization.
• Hands‑on laboratory experience required.
• Experience with biologics characterization and protein analytical methods.
• Proficiency with LC‑MS, glycan analysis, and chromatography.
• Ability to independently plan and execute experiments and communicate results.

Responsibilities

• Design, plan, execute, analyze, and report biologics characterization experiments.
• Perform analytical and biophysical studies on structure, purity, and stability.
• Apply LC‑MS, peptide mapping, intact mass, and other methods.
• Prepare technical reports and technology transfer documents.
• Lead characterization activities to support regulatory submissions.
• Coordinate internal or external characterization activities.
• Troubleshoot instrumental and data analysis issues.
• Mentor colleagues and train interns as needed.
• Present technical results internally and contribute to publications when applicable.

Skills

Mass spectrometry

Biophysical characterization

Chromatography

Data interpretation

IRB/ELN/LIMS familiarity

Experiment design

Test method development

Cross-functional communication

Education

Bachelor’s degree in analytical/biochem/biophysics

Master’s degree in analytical/biochem/biophysics

Ph.D. in related field (experience alternative)

Tools

LC‑MS

UPLC/HPLC

AUC

CD/DSC/DLS

Glycan analysis

Job description

Takeda is seeking a Scientist, Biologics Characterization in Lexington, MA to independently plan, execute, and report characterization studies supporting CMC, comparability, and regulatory submissions.

You will use mass spectrometry, biophysical methods, and LC‑UPLC separations, developing strategies and mentoring teammates while collaborating with cross‑functional partners. This role emphasizes data quality and scientific rigor.