Biologics Characterization Scientist - LC-MS & Analytics

USA - 3316 Takeda Development Center Americas, Inc.; Lexington (MA); On-site; USD 104,000 - 163,000; Full time

Job summary

Takeda in Lexington, MA is seeking an Analytical Development scientist focused on biologics characterization. You will independently plan, execute, and report experiments using LC-MS, peptide mapping, glycan analysis, and HPLC/UPLC methods to support product understanding and regulatory submissions.

The role emphasizes hands-on laboratory work, data integrity, and collaboration with cross-functional teams, with opportunities to train others and contribute to technology transfer efforts.

Qualifications

• Associate degree with 7+ years of relevant industry experience in analytical development, biologics characterization, protein chemistry, biophysics, analytical chemistry.
• Bachelor’s degree with 5+ years of relevant industry experience in analytical development or related field.
• Master’s degree with 3+ years of relevant industry experience in analytical development or related field.
• Hands-on laboratory experience required.
• Experience with biologics characterization, protein analytical methods, MS, biophysical characterization, chromatography, electrophoresis, or related analytical technologies.
• Knowledge of methods such as LC-MS, peptide mapping, intact mass, glycan analysis, SEC-HPLC, RP-HPLC, IEX-HPLC, HIC-HPLC, icIEF, CE-SDS, AUC, CD, DSC, DLS, SPR, fluorescence spectroscopy, or related techniques.
• Ability to independently plan and execute experiments, analyze data, and communicate conclusions to stakeholders.
• Understanding of biologics structure, heterogeneity, stability, degradation pathways, product-related variants, and critical quality attributes.
• Ability to prepare and review technical documentation (protocols, reports, SOPs, tech transfer).
• Problem-solving skills including troubleshooting and risk escalation.
• Ability to work across teams with timelines and data quality expectations.
• Understanding of data integrity principles and good documentation practices.
• Ability to manage multiple priorities with scientific rigor and documentation standards.
• Effective written and oral communication; ability to present to stakeholders.
• Comfort with emerging digital and AI-enabled tools for data analysis and workflow improvements.

Responsibilities

• Independently design, plan, execute, analyze, and report basic and complex biologics characterization experiments under general direction.
• Perform analytical and biophysical studies to assess structure, heterogeneity, purity, stability, and variants.
• Apply methods such as LC-MS, peptide mapping, intact mass, glycan analysis, HPLC/UPLC, electrophoretic methods, spectroscopy, or related tools.
• Prepare protocols, technical reports, data summaries, method documents, and technology transfer materials.
• Interpret and communicate results to teammates and cross-functional partners with alignment from supervisor or project lead.

Skills

LC-MS

Peptide mapping

Intact mass

Glycan analysis

HPLC/UPLC

AUC

CD

DSC

DLS

Spectroscopy

Biologics characterization

Education

Associate degree 7+ years

Bachelor’s degree 5+ years

Master’s degree 3+ years

Tools

SEC-HPLC

RP-HPLC

IEX-HPLC

HIC-HPLC

icIEF

CE-SDS

AUC

Job description

Takeda in Lexington, MA is seeking an Analytical Development scientist focused on biologics characterization. You will independently plan, execute, and report experiments using LC-MS, peptide mapping, glycan analysis, and HPLC/UPLC methods to support product understanding and regulatory submissions.

The role emphasizes hands-on laboratory work, data integrity, and collaboration with cross-functional teams, with opportunities to train others and contribute to technology transfer efforts.