Bioinformatics / Data Scientist

Axle; Rockville (MD); On-site; USD 105,000 - 120,000; Full time

Benefits offered by this job

100% Medical, Dental & Vision Coverage

401K match up to 5%

Educational Benefits for Career Growth

Employee Referral Bonus

Flexible Spending Accounts: Healthcare

Parking Reimbursement Account

Dependent Care Assistant Program

Transportation Reimbursement Account

Job summary

Axle in Rockville, MD seeks a Bioinformatics/Data Scientist to advance multi-omics analysis for organoid systems and corresponding normal tissues. This onsite role combines deep computational work with close collaboration across experimental teams, focusing on organoid fidelity, biomarker discovery, and computational quality assessment frameworks.

Compensation ranges from USD 105,000 to 120,000 per year. You will work on pipelines, QC, and results interpretation, contributing to manuscripts and

Qualifications

• PhD in bioinformatics, computational biology, biostatistics or related quantitative field.
• Extensive single-cell data analysis experience with Seurat/Scanpy or comparable platforms.
• Proficiency in R and Python with statistical analysis and data visualization.

Responsibilities

• Analyze multi-omics datasets including single-cell RNA-seq, bulk RNA-seq, proteomics and metabolomics from organoid systems and tissues.
• Collaborate with wet-lab teams to refine experiments and optimize protocols.
• Build and run computational pipelines for data processing, quality control and statistical analysis.
• Integrate SOM-generated data with public datasets to benchmark organoid characteristics against normal tissue profiles.
• Support protocol optimization and interpretation of results with experimental teams.
• Contribute to manuscript preparation and present findings at scientific conferences.

Skills

Single-cell data analysis

Statistical analysis

Data visualization

Machine learning basics

Education

PhD in bioinformatics/ computational biology/ biostatistics

Tools

R

Python

Seurat

Scanpy

Job description

Axle is seeking a Bioinformatics / Data Scientist to help advance multi-omics analysis for organoid systems and corresponding normal tissues. This onsite role in Rockville, MD combines deep computational work with close collaboration across experimental teams, with a focus on organoid fidelity characterization, biomarker discovery for successful differentiation, and the development of computational quality assessment frameworks.

Compensation: USD 105,000 - 120,000 per year.

What you’ll do

• Analyze complex multi-omics datasets, including single-cell RNA sequencing, bulk RNA sequencing, proteomics, and metabolomics from organoid systems and their tissue counterparts.
• Partner with experimental wet-lab teams to refine experimental design and optimize protocols for both knowledge discovery and performance.
• Build and run computational pipelines for data processing, quality control, and statistical analysis.
• Integrate SOM-generated data with publicly available datasets to benchmark organoid characteristics against normal tissue profiles.
• Collaborate with experimental teams to interpret results and support protocol optimization.
• Contribute to manuscript preparation and present findings at scientific conferences.

What you bring

• PhD in bioinformatics, computational biology, biostatistics, or a related quantitative field.
• Extensive experience with single-cell data analysis, including familiarity with Seurat, Scanpy, or comparable platforms.
• Strong programming proficiency in R and Python, plus experience with statistical analysis and data visualization.
• Basic knowledge of proteomics and metabolomics data.

Preferred background

• Prior experience analyzing organoid datasets.
• Experience with machine learning approaches for biological data, familiarity with pathway analysis tools, and knowledge of developmental biology principles.
• Experience working in high-performance computing environments and using version control systems.

Tools you’ll use

• R, Python, Seurat, Scanpy

Benefits

• 100% Medical, Dental & Vision Coverage for Employees
• Paid Time Off and Paid Holidays
• 401K match up to 5%
• Educational Benefits for Career Growth
• Employee Referral Bonus
• Flexible Spending Accounts: Healthcare (FSA)
• Parking Reimbursement Account (PRK)
• Dependent Care Assistant Program (DCAP)
• Transportation Reimbursement Account (TRN)