Data Scientist Fellow — Multi-Omics Analysis

Axle; Bethesda (MD); On-site; USD 90,000 - 100,000; Full time

Benefits offered by this job

Paid Time Off and Holidays

401K match up to 5%

Educational Benefits

Employee Referral Bonus

Flexible Spending Accounts: Healthcare

Job summary

Axle in Bethesda, MD seeks a Bioinformatics Fellow specializing in multi-omics analysis to advance organoid research. You will analyze single-cell RNA sequencing, proteomics, and metabolomics data, assess organoid fidelity, and identify biomarkers of differentiation.

Collaborating with experimental teams, you will develop scalable pipelines, apply machine learning to classify cellular states, and help prepare manuscripts for publication while preparing for an independent research career.

Qualifications

• Doctoral degree in bioinformatics, computational biology, biostatistics, or related quantitative field.
• Extensive single-cell data analysis experience using Seurat/Scanpy.

Responsibilities

• Multi-omics analysis of organoid data and tissue counterparts.
• Develop pipelines for data processing, QC, and statistics.
• Benchmark organoid characteristics against normal tissue profiles.
• Develop analytical methods including machine learning for cellular state classification.
• Collaborate with experimental teams and contribute to manuscript preparation.
• Present findings at scientific conferences.

Skills

Single-cell analysis

Programming (R and Python)

Statistical analysis

Data visualization

Education

PhD in bioinformatics/computational biology/biostatistics

Tools

Seurat

Scanpy

Job description

Data Scientist Fellow - Multi-Omics Analysis

Bethesda, MD

(ID: 2026-3889)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

Benefits We Offer:

• Paid Time Off and Paid Holidays
• 401K match up to 5%
• Educational Benefits for Career Growth
• Employee Referral Bonus
• Flexible Spending Accounts:
  • Healthcare (FSA)
  • Parking Reimbursement Account (PRK)
  • Dependent Care Assistant Program (DCAP)
  • Transportation Reimbursement Account (TRN)

Position Overview

The Bioinformatics Fellow for Multi-Omics Analysis will conduct comprehensive analyses of multi-omics data generated from organoid systems and corresponding normal tissues. The incumbent will characterize organoid fidelity, identify biomarkers of successful differentiation, and develop computational frameworks for organoid quality assessment, while gaining substantive training in integrative analysis of single-cell and multi-omics data. The work is central to the SOM Center’s research objectives, and the position is intended to prepare the Fellow for an independent research career in academia, government, or industry.

Key Responsibilities

• Multi-omics analysis. Analyze complex datasets including single-cell RNA sequencing, bulk RNA sequencing, proteomics, and metabolomics data from a range of organoid systems and their tissue counterparts.
• Pipeline development. Develop and implement computational pipelines for data processing, quality control, and statistical analysis, and document them so that analyses are reproducible across the Center.
• Benchmarking. Integrate SOM-generated data with publicly available datasets in order to benchmark organoid characteristics against normal tissue profiles.
• Method development. Develop and refine analytical approaches - including machine learning methods where appropriate - for classifying cellular states and assessing organoid quality, and contribute to standardized assessment protocols.
• Collaboration and interpretation. Work closely with experimental teams to interpret results and guide protocol optimization, and collaborate with other computational staff on cross-modality data integration.
• Dissemination. Contribute to manuscript preparation and present findings at scientific conferences.

Required Qualifications

• Education. Doctoral degree (PhD) in bioinformatics, computational biology, biostatistics, or a related quantitative field, completed or anticipated prior to the start of the appointment.
• Single-cell analysis. Extensive experience with single-cell data analysis, including familiarity with tools such as Seurat, Scanpy, or comparable platforms.
• Programming. Strong programming proficiency in R and Python, together with experience in statistical analysis and data visualization.
• Omics workflows. Working knowledge of proteomics and metabolomics data analysis workflows.

Preferred Qualifications

• Prior experience analyzing organoid datasets.
• Experience with machine learning approaches for biological data, familiarity with pathway analysis tools, and knowledge of developmental biology principles.
• Experience with high-performance computing environments and version control systems.

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: [e-mail]

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

#IND

Salary Range

$90,000 - $100,000 USD

Voluntary Self-Identification

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As set forth in Axle’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

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