Biochemist II - GMP Recombinant Protein Manufacturing

Revvity

San Diego (CA)

On-site

USD 28,000 - 41,000

Full time

14 days+

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Benefits offered by this job

Medical, Dental, and Vision Insurance

Life and Disability Insurance

Paid Time-Off

Parental Benefits

Compassionate Care Leave

401k with Company Match

Employee Stock Purchase Plan

Job summary

Revvity in San Diego, CA is seeking a GMP recombinant protein Biochemist responsible for purification, conjugation, formulation and quality control for GMP product release. This role supports manufacturing, manages batch records, materials, and collaborates with QA/QC teams to ensure ISO/GMP compliance.

Responsibilities include purification using IMAC and Protein A Sepharose, conjugation, in-process testing, and contributing to CAPA, training and validation efforts in a collaborative multitask

Qualifications

BS in Life Science or related field as minimum.
Extensive experience in protein or antibody purification.
Experience in ISO/GMP manufacturing environments.
Detail-oriented and able to work in small teams.

Responsibilities

Purify recombinant proteins using affinity matrices (IMAC, Protein A Sepharose).
Purify proteins and perform conjugation and polishing via chromatography/AKTA FPLC.
Conduct in-process quality testing such as purity and endotoxin.
Support internal safety and regulatory audits.
Assist with data entry, batch records, and equipment validation.

Skills

Protein purification

GMP ISO compliance

Quality control

Documentation & SOPs

Team collaboration

Education

Bachelor of Science in Life Science

Tools

AKTA FPLC

Protein A Sepharose

Job description

Job Summary

This GMP recombinant protein Biochemist at BioLegend will primarily be responsible for performing protein purification, conjugation, formulation, and quality control for GMP product release. This position will assist in GMP protein manufacturing for GMP products. The position plays an important part in the success of the robust GMP recombinant protein product manufacturing and will actively support team members in managing raw material, inventory, and batch records through efforts collaborating with other departments such as manufacturing, quality assurance, and quality control teams.

This Biochemist will perform purifying recombinant proteins using various preparative chromatography methods and separation using methods such as IMAC, size exclusion, and ion exchange, conjugation and formulate the recombinant proteins according to standard operating procedures compliant with ISO and GMP regulation.

This position will also support a variety of cross-function manufacturing tasks including work order processing and closure of pilot lots related to product release or validation.

His/her role also assists in activities for technical support, document control, validation, training, nonconformance, and CAPA systems.

Essential Functions

Following standard procedures to conduct recombinant protein or antibody purification using affinity matrix such as IMAC and Protein A Sepharose.
Following standard procedures to conduct protein conjugation and polishing using various types of chromatography and AKTA FPLC.
Conduct the in-process quality testing such as purity analysis, endotoxin testing for the in-house made or customized bulk material of finished goods.
Support internal safety and regulatory compliance audits
Support equipment operation training and validation activities for new process and equipment validation
Provide benchwork support for product releasing or troubleshooting of complicated manufacturing problems in recombinant protein production to ensure sustainable manufacturing design
Support reviewing of quality system documents and corrective actions (NCR, or CAR) to ensure laboratory setting and procedures are in compliance with ISO9001:2008/ 13485:2016
Proactively identify opportunities to improve current manufacturing procedures in order to increase efficiency and consistency to ensure QA compliance in traceability and equivalency.
Other projects or responsibilities may be required.

Minimum Qualifications – Education And Experience

Bachelor of Science in Life Science or related area.

Preferred Qualifications – Education And Experience

Bachler's Degree in Life Science or related area with at least 2 years of working experience in related biotech protein or antibody product manufacturing.
Extensive experience in protein or antibody purification.
Experienced in purification and formulation of recombinant protein or antibody.
Experienced in manufacturing under ISO/GMP environment.
Demonstrated ability to be detail-oriented, organized and work well in small work groups
Able to perform basic computer operations such as MS Office and Outlook and other computer-based software

Work Environment & Physical Demands

Lab

While performing the duties of this job, the employee regularly works in a laboratory environment with occasional data entry on a computer. Occasional exposure to a warehouse environment.

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

While performing the duties of this job, the employee is regularly required to use hands and fingers to handle, feel, or operate objects, tools or controls, and reach with hands and arms. The employee is frequently required to stand, talk and hear.

The base salary range for this full-time position is $20.00 - 30.00/hr. This range reflects the minimum and maximum target for a new hire in this position. The base pay actually offered to the successful candidate will take into account internal equity, work location, and additional factors, including job-related skills, experience, and relevant education or training.

Please note that base pay is only one part of our total compensation package and is determined within a range. This range allows for the successful candidate to have an opportunity to progress within the position and develop at our company. This base pay range does not take into account bonuses, equity, or other benefits which may be applicable and are dependent on the level and position offered.

What do we offer?

We provide competitive and comprehensive benefits to our employees. Below are some highlights of our benefits: