Biocatalysis and natural product biosynthesis

Wayne State University; Detroit (MI); On-site; USD 50,000 - 70,000; Full time

Job summary

The Jiang Group at Wayne State University is seeking a highly motivated postdoctoral research associate in biocatalysis and natural product biosynthesis. This role involves exploring enzymes to develop novel biocatalysts for synthesizing relevant compounds and fostering structural diversity for drug discovery.

The ideal candidate will have a Ph.D. in related disciplines and experience in laboratory techniques such as chemical synthesis and molecular biology. This position is perfect for recent doctoral graduates aiming to enhance their research skills.

Qualifications

• Ph.D. in medicinal chemistry, organic chemistry, chemical biology, molecular biology, biochemistry, or chemical engineering.
• Skills in small molecule synthesis and purification.
• Experience with chromatography and mass spectrometry methods.

Responsibilities

• Explore enzymes from diverse origins for novel biocatalysts.
• Conduct laboratory work in drug discovery and synthetic biology.

Skills

Small molecule chemical/enzymatic synthesis

Purification and characterization

Experience with 1D & 2D NMR

Experience with HPLC

Experience with LC-MS

Experience with GC-MS

Enzyme expression

Natural product isolation

Performing anticancer assays

Continuous flow techniques

Education

Ph.D. in medicinal chemistry or related disciplines

Job description

Summary

The Jiang Group at Wayne State University is seeking one highly motivated postdoctoral research associate in biocatalysis and natural product biosynthesis. The primary research objective is to explore enzymes from diverse origins to discover novel biocatalysts for synthesizing pharmaceutically relevant compounds and to create structural diversity of natural products for drug discovery. This position will involve laboratory work in drug discovery, biocatalysis, protein engineering, synthetic biology, molecular biology, and natural product biosynthesis, which is ideally suited for individuals who recently completed doctoral studies and hope to hone their skills in these areas.

Required qualifications

• A Ph.D. in medicinal chemistry, organic chemistry, chemical biology, molecular biology, biochemistry, chemical engineering, or related disciplines.

Preferred qualifications

• Skills in small molecule chemical/enzymatic synthesis, purification, and characterization.
• Experience with 1D & 2D NMR, HPLC, LC-MS, and GC-MS.
• Skills in enzyme expression, purification, and characterization.
• Experience in natural product isolation and biosynthesis.
• Skills in performing anticancer or antimicrobial assays.
• Skills in continuous flow.