Bacillus Strain Engineer — High-Throughput & Scale-Up

Alta Resource Technologies, Inc.; Boulder (CO); On-site; USD 82,000 - 120,000; Full time

Benefits offered by this job

Flexible Time Off

Company Holidays

Job summary

Alta Resource Technologies in Boulder, CO is seeking a Scientist I/II in Strain Engineering to apply genetic engineering, molecular biology, and metabolic modeling to improve expression of target proteins from a Bacillus host. This role will drive high-throughput screening and scale-up fermentation across teams.

You will collaborate with data scientists and bioproduction groups, develop robust protocols, and document methods with rigor.

Qualifications

• PhD in Synthetic Biology, Metabolic Engineering, Molecular Biology, Microbiology or a related field with 1-3+ years field-specific experience.
• Expertise in Bacillus biology and genetics.
• Experience in high-throughput molecular biology.
• Experience with metabolic engineering and profiling to optimize microbial hosts.
• Experience with automated workflow development.
• Experience with bioinformatics tools and sample management software.
• Demonstrated knowledge of experimental design, the scientific method, and statistical analysis.
• Strong written and verbal communication skills and ability to work within different teams.
• Strong organizational and documentation skills.
• Applicants must be authorized to work for ANY employer in the U.S.

Responsibilities

• Engineer Bacillus host strains and expression architectures using genetic manipulation techniques and molecular biology approaches.
• Leverage metabolic engineering and molecular assays towards protein expression optimization in relevant fermentation conditions to improve titer, rate, and yield.
• Develop and execute high-throughput screening assays to improve production hosts and architectures.
• Collaborate with data scientists, protein engineers, and the bioproduction team to achieve rapid scale-up of candidates determined through reliable plate-based screening approaches.
• Ensure excellent practices in documentation of all protocols and experiments.
• Effectively communicate results with stakeholders across the company.

Skills

Bacillus biology

High-throughput molecular biology

Metabolic engineering

Automated workflow development

Bioinformatics tools

Experimental design & statistics

Communication skills

Documentation skills

Education

PhD in Synthetic Biology, Metabolic Engineering, Molecular Biology, Microbiology or a related field

Job description

Alta Resource Technologies in Boulder, CO is seeking a Scientist I/II in Strain Engineering to apply genetic engineering, molecular biology, and metabolic modeling to improve expression of target proteins from a Bacillus host. This role will drive high-throughput screening and scale-up fermentation across teams.

You will collaborate with data scientists and bioproduction groups, develop robust protocols, and document methods with rigor.