Bioengineering Scientist: Strain & Enzyme Design

Manus Bio Inc.; Waltham (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

Manus Bio Inc. in Waltham, MA is seeking a Research Scientist for Strain and Enzyme Engineering. This full-time role focuses on engineering microbial strains and enzymes (primarily in E.

coli) to advance biosynthetic pathways for BioAlternatives. You will collaborate with process development to scale promising strains through bioreactors and contribute across the full development cycle. Applicants should have a PhD in a relevant field and hands-on experience with genetic engineering, pathway

Qualifications

• PhD or equivalent in a relevant biosciences field.
• Hands-on experience with genetic engineering tools including cloning and pathway assembly.
• Knowledge of enzyme engineering and DBTL workflows.
• Expertise in microbial physiology and metabolism.

Responsibilities

• Identify and address metabolic bottlenecks; design, construct, and optimize biosynthetic pathways.
• Apply DBTL to evaluate enzyme panels and engineered variants; improve pathway activity.
• Design, construct, and validate vectors for expression in microbial hosts.
• Construct E. coli strains using recombineering or CRISPR-based edits to support development campaigns.
• Develop high-throughput screening workflows to evaluate strain and enzyme performance.
• Operate GC and LC instrumentation to quantify titer, yield, and productivity.

Skills

Genetic engineering

Enzyme engineering

DBTL workflows

Microbial metabolism

Education

PhD in Bioengineering, Biochemistry, Microbiology, or related field

Tools

GC/LC instrumentation

LIMS data entry

Job description

Manus Bio Inc. in Waltham, MA is seeking a Research Scientist for Strain and Enzyme Engineering. This full-time role focuses on engineering microbial strains and enzymes (primarily in E.

coli) to advance biosynthetic pathways for BioAlternatives. You will collaborate with process development to scale promising strains through bioreactors and contribute across the full development cycle. Applicants should have a PhD in a relevant field and hands-on experience with genetic engineering, pathway