Associate Scientist – Next-Generation Sequencing (NGS)

SeqMatic LLC; Fremont (CA); On-site; USD 90,000 - 100,000; Full time

Job summary

SeqMatic LLC in Fremont, California, is seeking an Associate Scientist for Next-Generation Sequencing (NGS) operations. You will support onboarding of new services, optimize library prep workflows, and manage day-to-day lab activities to ensure high-quality outputs.

The successful candidate will have a strong NGS background, hands-on library prep experience, and a proven ability to drive process improvements in a dynamic environment.

Qualifications

• Master’s or Doctorate in a relevant field.
• 5+ years hands-on NGS lab experience.
• Strong expertise in library preparation (WGS, RNA-seq, panels).
• Experience in workflow optimization and assay development.
• Familiarity with Illumina, PacBio, Oxford Nanopore platforms.
• Excellent documentation and communication skills.

Responsibilities

• Lead onboarding of new NGS service offerings including workflow design, validation, and implementation.
• Develop, optimize, and troubleshoot library prep protocols across platforms.
• Execute daily NGS lab operations with high-quality outputs.
• Evaluate and improve workflows for efficiency, scalability, and turnaround.
• Collaborate with bioinformatics, operations, and quality teams.
• Document SOPs, validation reports, and process updates to quality standards.
• Train and mentor lab staff on new workflows and best practices.

Skills

NGS expertise

Library prep

Workflow optimization

Documentation

Troubleshooting

Cross-functional collaboration

Education

Master’s or PhD in Molecular Biology/Genomics/Biotechnology

Tools

Illumina platforms

PacBio

Oxford Nanopore

Job description

Associate Scientist – Next-Generation Sequencing (NGS)

SeqMatic LLC Fremont, California, United States

About this position

SeqMatic is a Next Generation Sequencing (NGS) and omics services provider based in the San Francisco South Bay Area. The company was founded in 2012 by former Illumina R&D scientists who are experts in the NGS workflow and related bioinformatics.

We specialize in Illumina NGS platforms, bulk DNA/RNA-seq, Single-cell RNA, as well as custom sequencing services with fast turnaround times. Our lab is CLIA / CAP certified. We recently expanded our capabilities beyond RUO to support clinical trials for our Clients, in addition to incorporating novel technologies such as Spatial Transcriptomics, Epigenetics, Proteomics and Histopathology.

Role Overview

We are looking for a detail-oriented and hands-on Scientist to support and expand our Next-Generation Sequencing (NGS) operations. This role will be instrumental in onboarding new services, developing and optimizing workflows, and supporting day-to-day NGS laboratory activities, particularly in library preparation.

The ideal candidate is highly organized, technically strong in NGS methods, and excited to drive process improvements in a dynamic lab environment.

Key Responsibilities

• Lead the onboarding of new NGS service offerings, including workflow design, validation, and implementation
• Develop, optimize, and troubleshoot NGS library preparation protocols across multiple platforms and applications
• Execute daily NGS lab operations, ensuring consistency, accuracy, and high-quality outputs
• Evaluate and improve existing workflows to enhance efficiency, scalability, and turnaround time
• Collaborate cross-functionally with bioinformatics, operations, and quality teams to ensure seamless service delivery
• Document SOPs, validation reports, and process updates in compliance with quality standards
• Train and mentor lab staff on new workflows and best practices

Qualifications

Required

• Master’s or Doctorate degree in Molecular Biology, Genomics, Biotechnology, or related field
• 5+ years of hands-on experience in an NGS laboratory environment
• Strong expertise in NGS library preparation techniques (e.g., WGS, RNA-seq, targeted panels, etc.)
• Experience in workflow optimization, assay development, or process improvement
• Familiarity with sequencing platforms (e.g., Illumina, PacBio, Oxford Nanopore)
• Strong attention to detail, analytical thinking, and troubleshooting skills
• Excellent documentation and communication abilities

Preferred

• Experience on-boarding new assays or services in a clinical or commercial lab setting
• Knowledge of quality systems (CLIA, CAP, GLP, or similar)
• Exposure to automation platforms for library preparation
• Basic understanding of NGS bioinformatic analysis workflows

Pay range

The pay range for this role is:
90,000 - 100,000 USD per year(Fremont Blvd)