Associate Scientist II, Oligonucleotide Chemistry

Arexera Therapeutics; Boston (MA); On-site; USD 80,000 - 110,000; Full time

Job summary

Atalanta Therapeutics is seeking an Associate Scientist II to join the Chemistry team to support the discovery, synthesis, purification, and characterization of chemically modified oligonucleotides for research and drug development. The Associate Scientist will work on projects using state-of-the-art synthesis and analytical instrumentation in a cutting-edge laboratory environment.

The successful candidate will have a chemistry background (Bachelor’s 2–5 years or Master’s 0–2 years) and hands-on

Qualifications

• Degree in chemistry with relevant experience
• Experience with oligonucleotide synthesis equipment required
• Hands-on with HPLC and LC-MS
• Strong organizational and record-keeping skills
• Commitment to scientific integrity and lab excellence

Responsibilities

• Operate automated oligonucleotide synthesizers to produce high-quality oligonucleotides
• Develop and optimize synthesis, deprotection, purification, and analytical methods
• Use HPLC and LC-MS for purification and analysis and aid in instrument maintenance
• Quantify and characterize oligonucleotides for in vitro and in vivo studies
• Coordinate production to support research timelines
• Maintain accurate records and inventory documentation
• Collaborate with cross-functional teams in a dynamic lab

Skills

Oligonucleotide synthesis

Analytical chemistry

Documentation

Education

Bachelor’s degree in Chemistry

Master’s degree in Chemistry

Tools

HPLC

LC-MS

Job description

COMPANY DESCRIPTION:

Atalanta Therapeutics is a biotechnology company developing innovative RNA interference (RNAi) therapeutics to address the underlying causes of severe neurological diseases. Through a differentiated RNAi platform, strategic biopharmaceutical partnerships, and a growing internal pipeline, Atalanta is advancing the next generation of RNAi medicines with the goal of delivering transformative therapies to patients.

Atalanta is committed to fostering a culture of integrity, respect, collaboration, innovation, continuous learning, and scientific excellence, where every team member has the opportunity to make a meaningful impact.

POSITION SUMMARY:

Atalanta Therapeutics is seeking a motivated Associate Scientist II to join the Chemistry team to support the discovery, synthesis, purification, and characterization of chemically modified oligonucleotides for research and drug development. The Associate Scientist will work as part of a team on various projects that are critical in advancing our research and development efforts, using state-of-the-art synthesis and analytical instrumentation. This individual will deliver oligonucleotides for research experiments, help maintain and troubleshoot equipment, and collaborate with cross-functional teams in a cutting-edge laboratory environment. Successful candidates will have strong analytical and problem-solving skills with an eagerness to learn and contribute to a dynamic team environment.

RESPONSIBILITIES:

• Operate and maintain automated oligonucleotide synthesizers (e.g., Dr. Oligo, ÄKTA Oligopilot, Mermade) to synthesize high-quality oligonucleotides.
• Contribute to the development and optimization of methods for oligonucleotide synthesis, deprotection, purification, and analytical characterization.
• Use HPLC and LC-MS for purifying and analyzing synthetic oligonucleotides as well as assist in instrument maintenance and troubleshooting
• Quantify and characterize oligonucleotides using UV spectroscopy and other analytical techniques to support in vitro and in vivo studies.
• Coordinate oligonucleotide production to support research and drug discovery timelines.
• Contribute to implementing quality control mechanisms and monitoring systems for consistent and reliable oligonucleotide production
• Perform routine maintenance and troubleshoot synthesis and analytical instrumentation to ensure reliable laboratory operations.
• Maintain accurate experimental records and production data, including oligonucleotide inventory and documentation.
• Work in close collaboration with team members across various functions to Collaborate with and learn from team members in a cross-functional environment

QUALIFICATIONS:

• A Bachelor’s degree in Chemistry or related scientific discipline with 2-5 years of professional work experience -OR- a Master’s degree in Chemistry or related scientific discipline with 0-2 years of professional work experience.
• Experience in using oligonucleotide synthesis equipment is required
• Previous experience in preparation of in vitro and in vivo dosing solutions is desirable
• Hands-on experience with analytical and preparative HPLC and LC-MS is preferred.
• Experience performing analytical characterization and quality assessment of synthetic oligonucleotides is preferred.
• Strong organizational and record keeping skills are essential
• A strong commitment to scientific integrity and laboratory excellence is required

We are committed to ensuring all employees, both current and future, receive fair and equitable pay. Base pay is one component of the total compensation package, and is determined within a range according to role, level, and location. This provides the opportunity for growth as you gain experience and develop within a role, while also allowing for differentiation based on performance. The base pay range for this role is between $80,000-$110,000 and reflects our good faith estimate of the minimum and maximum target for the position as of the date of posting and may be modified in the future. The final base pay within the range will be determined by work location and additional factors, including job-related skills, experience, relevant education or training, and market demand for your expertise.

Atalanta is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.