Associate Scientist II, Biology

Alnylam Pharmaceuticals, Inc.; United States; On-site; USD 68,000 - 101,000; Full time

Benefits offered by this job

Medical benefits

Dental benefits

Vision benefits

401(k) match

Wellness program

Job summary

Alnylam Pharmaceuticals, Inc. seeks an Associate Scientist II to advance RNAi therapeutic programs from bench to clinic.

You will design and execute studies in rodent disease models, run qPCR, ELISA, and western blot analyses, and support both in vivo and in vitro characterizations of drug activity. The role requires life sciences training with hands-on experience in molecular assays, rodent handling, and data interpretation.

Qualifications

• Bachelor's degree in a life sciences-related discipline with 1–3 years of experience or a Master's with 0–2 years of experience.
• Proficiency in RNA/DNA/protein analysis techniques including RNA isolation, ELISA, western blotting, and RT-qPCR.
• Experience with cell culture and basic laboratory techniques; experimental design skills.

Responsibilities

• Contribute to study design and execution of studies to characterize RNAi compounds in rodent disease models.
• Develop and conduct assays such as qPCR, western blot, and ELISA to support in vivo and in vitro studies.
• Perform in vitro and cell-based assays to characterize drug activity or mechanism of action.
• Perform in vivo procedures in rodents, including administration of therapeutics via established methods.
• Analyze and interpret data, prepare experimental reports and presentations, and develop protocols.

Skills

RNA/DNA/protein analysis techniques

RT-qPCR

ELISA

Western blotting

In vivo rodent studies

Data interpretation and reporting

Cell culture

Education

Bachelor's degree in life sciences

Master's degree in life sciences

Tools

qPCR machines

ELISA readers

Western blot equipment

Job description

OverviewWe are seeking a talented candidate to fill an Associate Scientist II position within Alnylam’s Research department. This position is an opportunity to potentially see one’s work progress from the bench to the clinic and positively impact patients’ lives. The successful candidate will support development of current therapeutic programs as part of a multidisciplinary team and be involved in the discovery of RNAi compounds for a variety of novel indications and support their entry into the clinic. The successful candidate will have background in biological sciences and be technically skilled in basic laboratory techniques. Responsibilities will include designing, developing, and executing studies in rodent disease models, evaluation of small interfering RNAs (siRNAs) in wild-type animals, and conducting the associated in vitro molecular-based assays such as transcript and protein quantitation. Collaborative curiosity, passion for science, and a desire to learn new techniques are a must.ResponsibilitiesContribute to study design and execution of studies to characterize compounds for RNAi therapeutic programs, including rodent disease models (or other preclinical models)Develop and conduct assays such as qPCR, western blot, and ELISA, that support in vivo and in vitro studiesPerform in vitro and cell-based assays to characterize drug activity or mechanism of actionPerform in vivo procedures in rodents, including administration of therapeutics via established methodologiesAnalyze and interpret the dataPrepare clearly articulated experimental reports and data presentationsPrepare and develop protocols and methodologiesPresent data to groups within and outside of ResearchQualificationsBachelors degree in a life sciences-related discipline such as Molecular Biology, Cell Biology, Genetics with 1-3 years relevant experience or a Masters degree with 1 year of relevant experienceProficiency in RNA/DNA/protein analysis techniques, including RNA isolation, ELISA, western blotting and RT-qPCRCell/tissue culture experienceBasic rodent in vivo skills is a plusExperience setting up rodent disease models is a plusAbility to perform and troubleshoot assays independently or with limited direction of supervisor(s)/project leader(s)Demonstrate keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously and independently analyze results, propose future directions and generate clear reportsMust be flexible, open to new tasks and challenges, and able to work on tight deadlinesProven ability to work in a team environment and across functional areasCover letter encouraged#LI-JR1U.S. Pay Range$67,600.00 - $101,400.00The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careersAbout AlnylamWe are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.