Associate Scientist II - Analytical Development

BioSpace; Boulder (CO); On-site; USD 110,000 - 125,000; Full time

Benefits offered by this job

Medical, dental, and vision coverage

401(k) savings plan

Flexible vacation policy

Tuition reimbursement program

Job summary

A leading pharmaceutical company in Boulder, CO is seeking a motivated Senior Associate Scientist for the Analytical Development team. The role involves hands-on method development for oligonucleotides, conducting analyses, and supporting technical operations. Candidates should have an MS degree with three years of experience or a BS degree with five years. Strong analytical skills and familiarity with cGMP practices are essential. The position offers a competitive salary and benefits, including medical coverage and a flexible vacation policy.

Qualifications

• Experience in analytical method development, transfer, and validation in a cGMP environment.
• Strong background in analytical methods for oligonucleotide therapeutics.
• Knowledge of GLP/GMP in a pharmaceutical environment.

Responsibilities

• Provide analytical lab support for Oligonucleotide early phase pipeline.
• Develop HPLC analytical methods for drug substances.
• Prepare analytical samples and analyze data.
• Contribute data for regulatory submissions.

Skills

Analytical method development

Data analysis using HPLC

Troubleshooting lab instruments

Excellent written communication

Education

MS with 3+ years of industrial experience

BS with 5+ years of industrial experience

Tools

UHPLC

LC-MS

HPLC

Job description

About The Department

The Boulder Site is home to the specialized technical operations/CMC team for oligonucleotides and RNAi therapeutics. The CMC team works alongside Quality, Regulatory, Technical Operations and RNAi Early Development professionals at our Boulder, Colorado facility and works closely with our teams in Lexington, Massachusetts. Together, we are driving change. Are you ready to make a difference.

The Position

Novo Nordisk is seeking a highly motivated senior associate scientist to join the Analytical Development team in Boulder, CO. The candidate will be responsible for hands‑on method development in the laboratory supporting analyses of phosphoramidites, oligonucleotides, intermediates and drug products. Experience in analytical method development, transfer, and validation in a cGMP environment with hands‑on experience using UHPLC’s, LC‑MS for amidites, oligonucleotides and intermediates is desired. This position will support therapeutic programs in multiple disease areas and be a key contributor in supporting the technical operations team for Novo Nordisk’s GalXC and GalXC+ RNA platform products.

Relationships

This position reports to the Associate Director, Analytical Development as an individual contributor. Daily interaction with other peers in analytical development and/or process development teams in support of early phase product pipeline.

Essential Functions

• Primary responsibility to provide analytical lab support for Novo Nordisk’s Oligonucleotide early phase pipeline.
• Development of robust IPRP, AX or mixed‑mode HPLC analytical methods for testing highly modified oligonucleotide drug substances, in‑process samples, custom starting materials and drug products.
• Prepare analytical samples, analyze and process data, primarily by HPLC, LC‑MS, KF, GC‑FID/MS, etc.
• Lead efforts in LC‑MS analysis for oligonucleotides and intermediates thereof in support of process development.
• Conduct and help design unique experiments to help in characterization of highly modified oligonucleotides.
• Conduct feasibility for finalized analytical methods in support of phase appropriate method qualifications as necessary.
• Operate, and troubleshoot lab instruments including but not limited to MS single quads, HPLC and UPLCs.
• Keep accurate records of the experiments utilizing GDP documentation and summarize the results in well communicated presentations or written reports.
• Contribute data for characterization and analytical sections of regulatory submissions.
• Possess excellent written and verbal communication skills.
• Conduct laboratory work in an efficient manner that ensures a safe working environment.

Qualifications

• MS with 3+ years of industrial experience, or BS with 5+ years of industrial experience.
• Strong background in the analytical development of methods for the analysis of oligonucleotide therapeutics.
• Experience with IP‑RP‑UHPLC, MS and AX‑HPLC analytical techniques using Agilent, Waters and/or Thermo UHPLC’s and associated software.
• In depth knowledge of GLP/GMP’s in a pharmaceutical environment.
• Excellent writing and communication skills and a demonstrated ability to work independently and with cross‑functional teams.

Compensation and Benefits

The base compensation range for this position is $110,000 to $125,000. Base compensation is determined based on a number of factors. The position is also eligible for a company bonus based on individual and company performance. Novo Nordisk offers long‑term incentive compensation and/or company vehicles depending on the position’s level or other company factors. Employees are also eligible to participate in company employee benefit programs including medical, dental and vision coverage; life insurance; disability insurance; 401(k) savings plan; flexible spending accounts; employee assistance program; tuition reimbursement program; and voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance and auto/home insurance. The Company also offers time off pursuant to its sick time policy, flexible vacation policy, and parental leave policy.

The job posting is anticipated to close on April 4, 2026. The Company may however extend this time‑period, in which case the posting will remain available on our careers website at www.novonordisk-us/careers.com.

About Novo Nordisk

We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At Novo Nordisk, we’re not chasing quick fixes – we’re creating lasting change for long‑term health. For over 100 years, we’ve been driven by a single purpose: to defeat serious chronic diseases and help millions of people live healthier lives. This dedication fuels our constant curiosity and inspires us to push the boundaries of what’s possible in healthcare. We embrace diverse perspectives, seek out bold ideas, and build partnerships rooted in shared purpose. Together, we’re making healthcare more accessible, treating and defeating diseases, and pioneering solutions that create change spanning generations. When you join us, you become part of something bigger – a legacy of impact that reaches far beyond today.

Equal Opportunity Employer

Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations.

If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at 1‑855‑411‑5290. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.