Associate Scientist I — Single-Cell Genomics & CRISPR

New York Genome Center; City of Niagara Falls (NY); On-site; USD 53,000 - 66,000; Full time

Job summary

The New York Genome Center (NYGC) invites applications for an Associate Scientist I to support multimodal single-cell perturbation research. You will help with mammalian cell culture, CRISPR perturbation, single-cell prep, and library generation, ensuring high-quality data and rigorous QC.

You will collaborate across groups to plan experiments, develop technologies, and maintain detailed lab records, reporting to the Functional Perturbation Lab lead investigator.

Qualifications

• Bachelor's degree in Molecular Biology, Biotechnology, Biochemistry, or related field required.
• At least two years of hands-on experience in a molecular biology, cell biology, genomics, or related research laboratory required.
• Demonstrated proficiency in at least one relevant experimental area (e.g., mammalian cell culture, molecular cloning, or single-cell genomics).
• Working knowledge of core molecular biology methods (DNA/RNA purification, quantification, PCR, gel electrophoresis).
• Experience with CRISPR perturbation, lentiviral production or transduction, single-cell preparation, flow cytometry, or NGS library prep preferred but not required.

Responsibilities

• Perform single-cell assays including cell preparation, quality control, library preparation, and sequencing library QC.
• Maintain mammalian cell cultures; perform cell counting, viability assessment, transfection or transduction, selection, and sample prep.
• Support CRISPR perturbation workflows, including construct prep, lentiviral production, transduction, selection, and evaluation.
• Perform molecular biology workflows (construct assembly, cloning, plasmid prep, lentiviral packaging, purification, PCR, library prep, antibody conjugation).
• Contribute to development, optimization, and troubleshooting of methods by planning experiments, interpreting QC results, and addressing failures.
• Own experimental workflows from planning to documentation and communication of results.
• Coordinate samples, reagents, timelines, and metadata across projects; maintain SOPs.

Skills

Molecular biology

Cell culture

CRISPR perturbation

Single-cell genomics

Communication skills

Experiment planning

Attention to detail

Data interpretation

Education

Bachelor's degree in Molecular Biology or related field

Tools

PCR

Gel electrophoresis

Lentiviral production

Flow cytometry

Next-generation sequencing library prep

Job description

The New York Genome Center (NYGC) invites applications for an Associate Scientist I to support multimodal single-cell perturbation research. You will help with mammalian cell culture, CRISPR perturbation, single-cell prep, and library generation, ensuring high-quality data and rigorous QC.

You will collaborate across groups to plan experiments, develop technologies, and maintain detailed lab records, reporting to the Functional Perturbation Lab lead investigator.