Associate Scientist, DMPK

ZipRecruiter; Madison (WI); On-site; USD 65,000 - 75,000; Full time

Job summary

A leading biopharmaceutical company is seeking an Associate Scientist I to join their DMPK team in Madison, WI. The role involves performing quantitative bioanalysis and requires a Bachelor's in chemistry along with some lab experience. The company offers competitive salaries with a solid benefits package.

Qualifications

• At least one year of experience in the pharmaceutical/CRO industry.
• Familiarity with lab equipment required.
• Knowledge of Good Documentation Practices preferred.

Responsibilities

• Perform routine quantitative bioanalysis in various biological matrices.
• Generate reliable, reproducible data and present findings to DMPK team.
• Maintain lab instrumentation and follow safe laboratory practices.

Skills

Analytical techniques

Communication

Teamwork

Time management

Education

Bachelor's degree in chemistry or related scientific field

Tools

HPLC

LC-MS/MS

Analytical balances

Centrifuges

Pipettes

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines to treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins involved in disease. The depth and versatility of our RNAi technologies enable us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, with a clinical pipeline including disease targets in the liver and lung, and a promising pipeline of preclinical candidates.

Our corporate headquarters is in Pasadena, CA, with research and development teams in Madison, WI, and San Diego, CA, and a state-of-the-art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking an Associate Scientist I to join the DMPK team. The Associate Scientist I will primarily focus on performing routine bioanalytical sample analysis. They will join a team of highly motivated and experienced chemists and biologists and contribute to the success of Arrowhead.

Responsibilities

1. Perform routine quantitative bioanalysis in various biological matrices (fluids and tissues) supporting DMPK pharmacokinetic and biodistribution preclinical studies under minimal supervision.
2. Generate reliable, reproducible data in a timely manner. Analyze, organize, and manage data independently. Present findings to the broader DMPK team.
3. Conduct peer reviews of data.
4. Set up and maintain lab instrumentation such as HPLC-FL and LC-MS/MS systems.
5. Evaluate assay and instrument performance, troubleshoot minor issues.
6. Maintain a well-documented laboratory notebook.
7. Follow safe laboratory practices.

Requirements

• Bachelor's degree in chemistry or related scientific field with at least one year of experience in the pharmaceutical/CRO industry.
• Familiarity with lab equipment such as analytical balances, centrifuges, and pipettes.
• Experience with analytical techniques, especially HPLC and/or HPLC-MS.
• Self-motivated team player capable of thriving in a fast-paced, dynamic, multidisciplinary, matrixed environment.
• Strong communication, teamwork, and time management skills, with effective interpersonal and written/verbal communication abilities.

Preferred Qualifications

• Experience with bioanalytical sample analysis (regulated or non-regulated).
• Familiarity with GxP regulatory guidance.
• Knowledge of Good Documentation Practices.

Salary range in Wisconsin: $65,000—$75,000 USD.

Arrowhead offers competitive salaries and excellent benefits.

All applicants must have authorization to work in the US.

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