Associate Scientist, DMPK

Arrowhead Pharmaceuticals; Madison (WI); On-site; USD 65,000 - 75,000; Full time

Job summary

An innovative biopharmaceutical company is seeking an Associate Scientist I to join its DMPK team in Madison, WI. This role focuses on performing bioanalytical sample analysis, contributing to the development of cutting-edge RNAi-based therapeutics. The ideal candidate will thrive in a dynamic environment, working collaboratively with experienced chemists and biologists. Responsibilities include conducting quantitative bioanalysis, managing data, and maintaining lab instrumentation. If you're passionate about advancing science and making a difference in patients' lives, this opportunity is perfect for you.

Benefits

Competitive Salaries

Excellent Benefits

Dynamic Work Environment

Qualifications

• Bachelor's degree in chemistry or related field with 1+ year of experience.
• Familiarity with lab equipment and analytical techniques.

Responsibilities

• Perform routine bioanalysis supporting DMPK studies with minimal supervision.
• Generate reliable data and present findings to the DMPK team.

Skills

HPLC

Analytical Techniques

Data Analysis

Communication Skills

Education

Bachelor’s Degree in Chemistry

Tools

HPLC-FL

LC-MS/MS

Analytical Balances

Centrifuges

Pipettes

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines to treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a natural mechanism in living cells that inhibits the expression of specific genes, affecting protein production. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead focuses on developing innovative drugs for diseases with a genetic basis, often characterized by overproduction of proteins involved in disease. The versatility of our RNAi technologies allows us to address conditions across various therapeutic areas, including targets not accessible by small molecules and biologics. We are leading the field in applying RNAi to diseases outside the liver, with clinical pipelines targeting liver and lung diseases, along with promising preclinical candidates.

Our corporate headquarters is in Pasadena, CA, with research and development teams in Madison, WI, and San Diego, CA. Our employees are nimble, science-driven innovators collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking an Associate Scientist I to join the DMPK team. The primary focus will be on performing routine bioanalytical sample analysis. The successful candidate will join a team of highly motivated and experienced chemists and biologists, contributing to Arrowhead’s success.

Responsibilities

1. Perform routine quantitative bioanalysis in various biological matrices (fluids and tissues) supporting DMPK pharmacokinetic and biodistribution preclinical studies with minimal supervision.
2. Generate reliable, reproducible data promptly. Analyze, organize, and manage data independently. Present findings to the broader DMPK team.
3. Conduct peer reviews of data.
4. Set up and maintain lab instrumentation such as HPLC-FL and LC-MS/MS systems.
5. Evaluate assay and instrument performance, troubleshoot minor issues.
6. Maintain detailed laboratory notebooks.
7. Follow safe laboratory practices.

Requirements

1. Bachelor’s degree in chemistry or related scientific field with at least one year of experience in the pharmaceutical or CRO industry.
2. Familiarity with lab equipment like analytical balances, centrifuges, and pipettes.
3. Experience with analytical techniques, especially HPLC and/or HPLC-MS.
4. Self-motivated team player capable of thriving in a fast-paced, dynamic, multidisciplinary environment.
5. Strong communication, teamwork, and time management skills, with effective interpersonal and written/verbal communication.

Preferred

1. Experience with bioanalytical sample analysis (regulated or non-regulated).
2. Familiarity with GxP regulatory guidance.
3. Knowledge of Good Documentation Practices.

Salary range in Wisconsin: $65,000—$75,000 USD. Arrowhead offers competitive salaries and excellent benefits. Applicants must have authorization to work in the US.