Associate Scientist - Cellular Assay Development, Functional Genomics

BioSpace; Thousand Oaks (CA); On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

Retirement and Savings Plan

Medical, dental and vision coverage

Stock-based long-term incentives

Flexible work models

Job summary

Amgen in Thousand Oaks is seeking an Associate Scientist - Cellular Assay Development, Functional Genomics. You will be part of a dynamic, cross-functional team advancing target and biological discovery across therapeutic areas.

Responsibilities include executing functional arrayed genomic screens, maintaining mammalian cell cultures, and optimizing assays for high-throughput screening, with emphasis on translational insights and collaboration across TD&B and automation.

Qualifications

• Masters degree with relevant research experience in drug discovery.
• OR Bachelor's degree with 3+ years in scientific discovery.
• Experience with mammalian cell culture is essential.

Responsibilities

• Support functional arrayed genomic screens in advanced in vitro models.
• Perform mammalian cell culture, transfection, transduction, and functional assays.
• Optimize and miniaturize cell-based assays for high-throughput screening.
• Leverage functional assays, especially high-content imaging, to profile cellular phenotypes.
• Collaborate with TD&B and automation teams to accelerate model deployment.
• Collaborate with therapeutic-area scientists to deliver translational insights.
• Foster a collaborative and scientifically rigorous team culture.

Skills

Cell biology

Mammalian cell culture

iPSC culture

Gene editing

CRISPR/Cas9

High-content imaging

Cross-functional collaboration

Education

Master's degree in cell biology

Master's degree in molecular biology

Bachelor's with commensurate experience

Tools

CRISPR/Cas9

Lentiviral transduction

Plate-based assays

Automated screening

High-content imaging platforms

Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Associate Scientist - Cellular Assay Development, Functional Genomics

What You Will Do

Lets do this. Lets change the world. In this vital role you will be part of a dynamic, cross-functional team to advance target and biological discovery across Amgens therapeutic areas.

Key Responsibilities

• Support the execution of functional arrayed genomic screens inadvanced invitro modelsin collaboration with therapeutic area partners.
• Carry out mammalian cell culture, transfection, transduction, and functional assays toenable functional, arrayedgenomic screens; experience with iPSC culture and differentiation preferred.
• Optimizeand miniaturize cell-based assays for high-throughput automated screening.
• Leverage functional assays, particularly high-content imaging,to profile cellular phenotypes and states.
• Partner with TD&B and cross-functional team members, including automation colleagues, toaccelerate model deployment and reproducibility.
• Collaborate with Amgen therapeutic area scientists to define requirements, ensure biological relevance, and deliver systems that enable mechanistic and translational insights.
• Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgens pipeline.

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients. The Associate Scientist we seek is a researcher with these qualifications.

Basic Qualifications

Masters degree and 1 year of scientific/drug discovery experience andtrack recordof scientific excellence and productivity

OR

Bachelors degree and 3 years of scientific/drug discovery experience andtrack recordof scientific excellence and productivity

Preferred Qualifications

• M.S.degree in cell biology, molecular biology, biomedical engineering, or related discipline, or B.S. degree withcommensuratescientific/drug discovery experience andtrack recordof scientific excellence and productivity
• Proficiencywith mammalian cell culture,including immortalized and primary linesrequired; experience with iPSC culture preferred
• Experience with gene editing/delivery techniques,i.e.CRISPR/Cas9, lentiviral transduction, and transient transfection
• Experience withcellularassay optimization and miniaturization;familiarity working with plate-based assays and associated equipment/automation
• Strong hands-on experience with functional assays, particularly high-content imaging
• Familiarity withhigh-throughputsreeningmetrics (e.g.Z,S/B, MSMR)
• Demonstrated ability to collaborate with cross-functional teams to translate disease biology into experimental models
• Excellent organizational and communication skills, with the ability to drive cross-site collaboration in a matrixed research environment

What You Can Expect Of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In Addition To The Base Salary, Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities That May Include

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.