Associate Scientist - Cellular Assay Development, Functional Genomics

Amgen Inc. (IR); Thousand Oaks (CA); On-site; USD 94,000 - 128,000; Full time

Benefits offered by this job

Stock-based long-term incentives

Award-winning time-off plans

Job summary

Amgen Inc. (IR) is seeking an Associate Scientist – Cellular Assay Development, Functional Genomics, to join a cross-functional team advancing target and biological discovery across therapeutic areas.

The role focuses on functional arrayed genomic screens in advanced in vitro models, mammalian cell culture, and high-content imaging to profile cellular phenotypes. Preferred candidates hold a Master’s degree with experience or a Bachelor’s degree with extensive scientific/drug discovery

Qualifications

• Master’s degree and 1 year of scientific/drug discovery experience or Bachelor’s degree with 3 years of experience.
• Proficiency with mammalian cell culture; iPSC culture preferred.
• Experience with gene editing/delivery techniques such as CRISPR/Cas9 and lentiviral delivery.
• Experience with cellular assay optimization and miniaturization; plate-based assays.
• Strong hands-on experience with functional assays, especially high-content imaging.

Responsibilities

• Support execution of functional arrayed genomic screens in advanced in vitro models.
• Carry out mammalian cell culture, transfection, transduction, and functional assays.
• Optimize and miniaturize cell-based assays for high-throughput screening.
• Leverage functional assays to profile cellular phenotypes and states.
• Collaborate with TD&B and automation colleagues to accelerate model deployment.

Skills

Mammalian cell culture

iPSC culture

CRISPR/Cas9

Lentiviral transduction

Transient transfection

High-content imaging

High-throughput screening

Education

Master’s degree in relevant field

Bachelor’s degree with 3 years’ experience

Job description

Career Category Scientific Job Description

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Associate Scientist - Cellular Assay Development, Functional Genomics

What you will do Let’s do this. Let’s change the world. In this vital role you will be part of a dynamic, cross-functional team to advance target and biological discovery across Amgen’s therapeutic areas.

Key Responsibilities

• Support the execution of functional arrayed genomic screens in advanced in vitro models in collaboration with therapeutic area partners.
• Carry out mammalian cell culture, transfection, transduction, and functional assays to enable functional, arrayed genomic screens; experience with iPSC culture and differentiation preferred.
• Optimize and miniaturize cell-based assays for high-throughput automated screening.
• Leverage functional assays, particularly high-content imaging, to profile cellular phenotypes and states.
• Partner with TD&B and cross-functional team members, including automation colleagues, to accelerate model deployment and reproducibility.
• Collaborate with Amgen therapeutic area scientists to define requirements, ensure biological relevance, and deliver systems that enable mechanistic and translational insights.
• Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Associate Scientist we seek is a researcher with these qualifications.

Basic Qualifications

• Master’s degree and 1 year of scientific/drug discovery experience and track record of scientific excellence and productivity OR Bachelor’s degree and 3 years of scientific/drug discovery experience and track record of scientific excellence and productivity

Preferred Qualifications

• M.S. degree in cell biology, molecular biology, biomedical engineering, or related discipline, or B.S. degree with commensurate scientific/drug discovery experience and track record of scientific excellence and productivity
• Proficiency with mammalian cell culture, including immortalized and primary lines required; experience with iPSC culture preferred
• Experience with gene editing/delivery techniques, i.e. CRISPR/Cas9, lentiviral transduction, and transient transfection
• Experience with cellular assay optimization and miniaturization; familiarity working with plate-based assays and associated equipment/automation
• Strong hands-on experience with functional assays, particularly high-content imaging
• Familiarity with high-throughput screening metrics (e.g. Z’, S/B, MSMR)
• Demonstrated ability to collaborate with cross-functional teams to translate disease biology into experimental models
• Excellent organizational and communication skills, with the ability to drive cross-site collaboration in a matrixed research environment

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Salary Range 94,340.65USD -127,637.35 USD

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Sponsorship

Sponsorship for this role is not guaranteed.

Accommodations

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

For more information, visit www.amgen.com and follow us on www.twitter.com/amgen