Associate Scientist, In vivo Pharmacology, Inflammation

Amgen Inc. (IR); South San Francisco (CA); On-site; USD 109,000 - 124,000; Full time

Benefits offered by this job

Retirement plan

Medical, dental & vision

Stock-based incentives

Discretionary annual bonus

Flexible time-off

Job summary

Amgen Inc. (IR) in South San Francisco seeks an Associate Scientist in In vivo Pharmacology to advance inflammation pipelines. You will perform in vivo and in vitro work, support dosing and tissue collection, and collaborate with scientists to design experiments and interpret results.

Ideal candidates have strong immunology background, experience with concurrent studies, and proficiency in flow cytometry and analytical software. The role emphasizes meticulous data handling and team collaboration.

Qualifications

• Master’s degree with 1 year Immunology or related experience, or Bachelor’s with 3 years of Immunology or related experience.
• Preferred MS in Immunology or BS with commensurate experience and productivity.
• Strong understanding of Immunology and inflammation biology.
• Experience in designing/conducting in vivo preclinical inflammation models.
• Hands-on in vivo techniques: multiple routes of administration and necropsy.
• Experience with ELISA, qRT-PCR, and protein assays; flow cytometry required.

Responsibilities

• Execute in vivo work in mouse models and support dosing, tissue collection, and health checks.
• Collaborate with Scientists to design experiments and interpret data.
• Run concurrent studies and manage timelines with attention to detail.
• Perform in vitro assays as needed and communicate results clearly.

Skills

Immunology

In vivo pharmacology

Mice models

Dosing & sample collection

Flow cytometry

GraphPad Prism

Excel

Team collaboration

Education

Master’s degree in Immunology or related field

Bachelor’s degree with 3 years Immunology or related experience

Tools

GraphPad Prism

Excel

PowerPoint

Word

Job description

Career Category Scientific Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Associate Scientist, In vivo Pharmacology, Inflammation

What you will do Let’s do this. Let’s change the world. In this vital role you will work in a highly dynamic in vivo pharmacology team executing in vivo preclinical disease models and in vitro assays in the vivarium and lab supporting pipeline programs.

Key Responsibilities

• Perform hands-on in vivo work primarily mice, possibly rats in the vivarium daily.
• Provide technical support for studies, dosing, sample/tissue collection, health checks, study setup and take down.
• Work side-by-side with Scientists/Senior Scientists to execute and help design experiments.
• Run concurrent studies, stay organized and detail-oriented to meet study timelines
• Participate in weekend/evening dosing rotations as needed
• Support in vitro assays as required
• Communicate results to immediate team and follow established protocols and safety procedures
• Work in a flexible team-oriented environment. Weekend and evening work may be required.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Associate Scientist we seek is a driven, pro‑active, independent, and enthusiastic scientist who wants to contribute to cutting‑edge science and serve patients in a highly productive team environment with these qualifications.

Basic Qualifications

• Master’s degree and 1 year of Immunology or related experience OR Bachelor’s degree and 3 years of Immunology or related experience

Preferred Qualifications

• M.S. degree in Immunology or related disciplines, or B.S. degree with commensurate scientific / drug discovery experience and track record of scientific excellence and productivity.
• Strong understanding of Immunology and Inflammation biology and principles.
• Willingness and curiosity to learn and explore new areas of research.
• Significant experience designing and executing concurrent in vivo preclinical inflammation and autoimmune disease models.
• Experience with colitis (DSS, CD45RBhi T cell transfer, IL-10 KO), lupus (NZB/W, MRL-lpr, Imiquimod), and arthritis (CIA, CAIA), GvHD models preferred.
• Experience in Asthma, COPD, HS, PBC a plus.
• Hands-on experience with in vivo techniques including dosing route of administration (i.v., i.p., p.o., i.n., i.t., r.o., i.d., s.c.), bleeds (r.o., cheek, tail), necropsy (organ collection (intestine/colon, lung, lymphnodes, spleen, liver, kidney, skin), cardiac bleed, lung BAL collection).
• Hands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, quantitative RT-PCR, BCA protein measurements) preferred.
• Hands-on experience with multicolor flow cytometry including Spectral flow approaches and Immune cell populations is essential.
• Computer literacy, especially proficiency with GraphPad Prism, Excel, PowerPoint and Word.
• Attention to detail, excellent organizational and communication skills, accurate & timely record keeping and data analysis are essential.
• Demonstrated track record of independent critical thinking and scientific achievement.
• Demonstrated experience in pharmacology and in vivo models of inflammation/Immunology.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Salary Range 108,862.00 USD - 124,469.00 USD

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world’s leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. For more information, visit www.amgen.com and follow us on www.twitter.com/amgen