Associate Research Scientist

Columbia University in the City of New York; New York (NY); On-site; USD 90,000 - 130,000; Full time

Job summary

The Laboratory of Dr. Andrew R. Marks at Columbia University Irving Medical Center seeks an Associate Research Scientist to lead studies on the ryanodine receptor (RyR) in normal and diseased physiology.

The role includes directing projects in cardiac and brain function using animal models and overseeing junior staff. Applicants should hold a PhD or MD/PhD with strong publications and experience in molecular biology, biochemistry, calcium signaling, protein purification, electrophysiology, and

Qualifications

• PhD or MD/PhD required with outstanding publications.
• Experience in molecular biology, biochemistry, calcium signaling, and protein purification.
• Proven ability to work independently and manage projects.
• Experience in electrophysiology and animal studies including heart failure models.

Responsibilities

• Lead projects investigating RyR roles in normal and pathological physiology.
• Perform echocardiography, ECGs and physiology measurements in animal models.
• Oversee junior staff and help implement lab protocols.

Skills

Oral communication

Written communication

Organizational skills

Independent work

Molecular biology

Biochemistry

Calcium signaling

Electrophysiology

Cell biology

Animal studies

Heart failure models

Education

PhD or MD/PhD

Tools

Protein purification

Echocardiography

ECG analysis

Calcium imaging

Job description

The laboratory of Dr. Andrew R. Marks, Chair, Department of Physiology and Cellular Biophysics at Columbia University Irving Medical Center, is seeking an Associate Research Scientist to lead projects in investigating the role of the ryanodine receptor (RyR), a calcium channel, in normal and pathological physiology. Abnormal calcium handling has been implicated in several diseases, and one of the candidate’s primary duties will be to investigate the role of RyR in pathophysiology using several unique animal models. The Associate Research Scientist will lead the lab’s effort to study cardiac and brain function and physiology in these animal models. The Associate Research Scientist position will also be responsible for overseeing the work of more junior research staff and may direct the implementation of laboratory processes/protocols. We are translating fundamental discoveries into ongoing clinical trials. Recent laboratory members have gone on to leading academic and pharmaceutical industry positions.

Responsibilities

• Performing echocardiography, ECGs, and LTP measurements in animal models, investigating protein biochemistry and purification, analyzing protein-protein interactions, studying intracellular calcium handling in isolated cells, as well as single channel analysis of the ryanodine receptor isolated from normal and diseased tissue.
• Overseeing the work of more junior research staff and may direct the implementation of laboratory processes/protocols.

Qualifications

• All applicants should have a PhD or MD/PhD, outstanding publications, oral and written communication skills, organizational skills, work ethic, the ability to work independently, and experience in molecular biology, biochemistry, calcium signaling, protein purification, electrophysiology, and/or animal studies including heart failure models.

Tagged as: Life Sciences