Associate Research Scientist

GenomeWeb; New York (NY); On-site; USD 90,000 - 120,000; Full time

Job summary

Columbia University Irving Medical Center in New York is seeking an Associate Research Scientist to lead projects on the ryanodine receptor (RyR) in normal and diseased physiology. You will lead the lab’s efforts to study cardiac and brain function in animal models, including echocardiography, ECGs, and calcium signaling analyses, driving translational insights toward clinical trials.

The ideal candidate holds a PhD or MD/PhD with outstanding publications and communications skills, and has

Qualifications

• PhD or MD/PhD with strong publications.
• Excellent oral and written communication skills.
• Organizational skills and ability to work independently.
• Experience in molecular biology, biochemistry, calcium signaling, protein purification, electrophysiology, and/or animal studies including heart failure models.

Responsibilities

• Lead RyR-focused projects in normal and diseased physiology.
• Perform echocardiography, ECGs, and calcium handling analyses in animal models.
• Oversee junior staff and help implement lab protocols.
• Translate laboratory findings toward clinical trial contexts.

Skills

Molecular biology

Biochemistry

Calcium signaling

Protein purification

Electrophysiology

Echocardiography

ECG

Animal studies

Lab leadership

Education

PhD or MD/PhD

Job description

The laboratory of Dr. Andrew R. Marks, Chair, Department of Physiology and Cellular Biophysics at Columbia University Irving Medical Center, is seeking an Associate Research Scientist to lead projects in investigating the role of the ryanodine receptor (RyR), a calcium channel, in normal and pathological physiology. Abnormal calcium handling has been implicated in several diseases, and one of the candidate’s primary duties will be to investigate the role of RyR in pathophysiology using several unique animal models. The Associate Research Scientist will lead the lab’s effort to study cardiac and brain function and physiology in these animal models. Responsibilities will include performing echocardiography, ECGs, and LTP measurements in animal models, investigating protein biochemistry and purification, analyzing protein-protein interactions, studying intracellular calcium handling in isolated cells, as well as single channel analysis of the ryanodine receptor isolated from normal and diseased tissue. The Associate Research Scientist position will also be responsible for overseeing the work of more junior research staff and may direct the implementation of laboratory processes/protocols. We are translating fundamental discoveries into ongoing clinical trials. Recent laboratory members have gone on to leading academic and pharmaceutical industry positions.

Requirements

All applicants should have a PhD or MD/PhD, outstanding publications, oral and written communication skills, organizational skills, work ethic, the ability to work independently, and experience in molecular biology, biochemistry, calcium signaling, protein purification, electrophysiology, and/or animal studies including heart failure models.

Columbia University Irving Medical Center (CUIMC) is a clinical, research, and educational enterprise located on a campus in northern Manhattan. We are home to four professional colleges and schools that provide global leadership in scientific research, health and medical education, and patient care, including:

Vagelos College of Physicians and Surgeons