Associate Principal Scientist, Regenerative Immunology

BioSpace; Englewood (NJ); On-site; USD 160,000 - 215,000; Full time

Job summary

ICR is seeking a Principal Scientist to lead the Thymic Regeneration Team in the Regenerative Immunology program. You will direct efforts to regenerate thymic function and rejuvenate adaptive immunity using iPSC-derived TECs and thymic organoids.

The role requires a PhD or MD/PhD, 10+ years of thymic biology and stem cell experience, and a strong track record in translational immunology and regenerative medicine.

Qualifications

• PhD or MD/PhD in a relevant field.
• 10+ years of research experience in thymic biology or regenerative immunology.
• Deep knowledge of thymic epithelial cell biology and iPSC differentiation.
• Experience with organoid engineering and immune reconstitution.

Responsibilities

• Lead a team developing iPSC-derived thymic epithelial cells (iTECs) and thymic organoids.
• Design and optimize directed-differentiation protocols to generate functional TECs from human iPSCs.
• Collaborate with ICR scientists to advance immune rejuvenation under a personalized medicine paradigm.

Skills

Immunology

Thymic biology

iPSC differentiation

Organoid engineering

T-cell development

CRISPR editing

Flow cytometry

Single-cell RNAseq

In vivo transplantation

Team leadership

Education

PhD or MD/PhD

Job description

ICR's Regenerative Immunology program is focused on regenerating the aging immune system, the decline of which underlies many of the most devastating age-related diseases. We're hiring a Principal Scientist to lead our Thymic Regeneration Team to restore thymic function and rejuvenate adaptive immunity. You'll need a deep background in immunology, thymic biology and iPSCs.

With ICR, You'll Get To

• Lead a cutting-edge team developing iPSC-derived thymic epithelial cells (iTECs) and thymic organoids to rejuvenate the aging immune system
• Contribute highly practical and readily translatable thymic regeneration, immune reconstitution and rejuvenative medicine ideas
• Design and optimize directed-differentiation protocols to generate functional, TECs from human iPSCs
• Collaborate with other ICR scientists and groups to advance immune rejuvenation under a personalized medicine paradigm

Requirements

• A PhD or MD/PhD
• At least 10 years of research experience, preferably in thymic biology, stem cell differentiation, organoid engineering or regenerative immunology
• Current and in-depth knowledge of thymic epithelial cell biology, iPSC directed differentiation, T-cell development and tissue engineering
• Expert knowledge in experimental therapeutics and the landscape of developmental pipelines of practical, actionable interventions to treat and prevent age-related immune senescence and achieve immune regeneration/rejuvenation

Ideally, You'll Have

• Expert knowledge of thymic epithelial cell ontogeny, FOXN1 biology, T-cell selection and thymic niche reconstitution
• Experience with iPSC culture, directed differentiation, 3D organoid culture, single-cell genomics, RNAseq, flow cytometry, immunofluorescent microscopy, CRISPR gene editing and cell culture
• Experience with in vivo transplantation, humanized mouse models and assessment of functional immune reconstitution

Additional Requirements

• A friendly, easygoing personality
• The ability to work in the United States without sponsorship

Salary

• Starting base pay range: $160,000/yr - $215,000/yr
• Starting additional compensation range: $10,000/yr - $20,000/yr