Associate I, Technical Development Operations

Lancesoft; South San Francisco (CA); On-site; USD 60,000 - 85,000; Full time

Job summary

Lancesoft in South San Francisco, CA is hiring for an Associate I in downstream process development within the Cell and Gene Therapy Research Division. You will perform downstream experiments, operate purification steps, and document results in a fast-paced, team-oriented lab environment located at 480 Forbes Blvd.

The role requires a BS in Life Science or Engineering (or equivalent) and 0–2+ years in pharma/biologics labs, with readiness for occasional overtime and strong communication skills.

Qualifications

• BS in Life Science or Engineering, or equivalent experience; Associate I requires 0-2+ years in pharma/biologics lab.
• Understanding of downstream process theory and equipment operation in biotech settings.
• Strong documentation and record-keeping with MS Office proficiency.
• Willingness to work outside normal hours and occasional weekends.

Responsibilities

• Perform operations per internal policies and requirements.
• Execute downstream process development experiments.
• Support downstream purification unit operations (chromatography, filtration).
• Operate production equipment, including setup, processing, and cleaning.
• Maintain safety procedures and a safe work environment.
• Document and maintain records for process development and AAV production.
• Maintain digital records in in-house systems and shared repositories.
• Onsite lab work and collaboration in a team-based setting.

Skills

Downstream process theory

Documentation skills

MS Office

Team collaboration

Communication skills

Problem solving

Laboratory experience

Education

BS in Life Science or Engineering

Associate I: 0-2+ years pharma/biologics lab experience

Tools

Chromatography equipment

Tangential Flow Filtration

Sterile filtration systems

Single-use technologies

Job description

Work Location: 480 Forbes Blvd, South San Francisco, CA, USA 94080

Purpose & Scope: This position reports to the Lead, Technical Department Operations in the Technical Development Department within the Cell and Gene Therapy Research Division. The associate will participate in downstream areas of AAV development and production within process development for gene therapy programs and processes. This position will be located in South San Francisco, CA.

Essential Job Responsibilities:

• Perform all operations as directed per internal policies and other requirements.
• Execute experiments for downstream process development activities
• Support downstream purification unit operations (such as chromatography, clarification, tangential flow filtration, sterile filtration, column packing, etc.)
• Operate production equipment, including inspection, set up, processing, and cleaning
• Establish operating equipment specifications and improve operational techniques
• Execute corrective measures addressing any issues in a timely manner
• Attend safety meetings and follow all safety procedures as defined, including maintaining a safe work environment for both self and colleagues.
• Execute corrective measures addressing any issues in a timely manner
• Ability to contribute to process improvement plans and help drive to completion
• Conduct operations in a collaborative, team environment with a positive attitude to accomplish goals
• Assist with process development experiments following defined experimental plans for non-GMP supply
• Document preparation and maintenance for process development and research grade AAV production operations.
• Maintain digital records of all research production activities using in-house systems and shared digital document repositories.
• Follow laboratory safety procedures.
• Other duties as assigned
• This is a lab and office-centric position that requires onsite work.

Qualifications:

• Required BS in Life Science or Engineering or equivalent experience Associate I: 0-2+ years of experience working in a pharmaceutical/biologics lab or manufacturing environment Display understanding of downstream process theory (i.E., Depth Filtration, Harvest, Tangential Flow Filtration, Column Chromatography) and equipment operation Strong communicator with ability to work effectively both independently and as part of a team Demonstrated experience in maintaining detailed records and ability to assist in document revisions Strong computer skills including MS Office (Word, Excel, PowerPoint) Effective problem-solving skills Available to work outside of normal business hours and/or overtime as required (occasional weekend work) Preferred Experience in biologics (protein, enzyme, AAV) purification Technical understanding of a biotech manufacturing facility Experience with single-use technologies Working knowledge of disposable manufacturing methodology such as the use of sterile bags with tubing and tubing welders Ability to multi-task, be flexible and to thrive in a fast-paced environment, as well as the capacity to handle uncertainty and changing priorities