Associate Director, Precision Medicine

Bristol-Myers Squibb Co; Virginia; Hybrid; USD 209,000 - 254,000; Full time

Benefits offered by this job

Flexible Time Off

11 paid company holidays

Comprehensive benefits package

Job summary

Bristol-Myers Squibb Co. seeks an expert in Model‑Informed Drug Development to lead the MIDD strategy across clinical programs. You will partner with Clinical Pharmacology and quantitative teams to guide dose selection, study hypotheses, and regulatory submissions using PMx models.

The role emphasizes translating complex modeling into clear decisions, mentoring scientists, and advancing PMx tooling, with a hybrid work model and strong emphasis on cross‑functional impact.

Qualifications

• Advanced degree in a relevant quantitative field (MS/PhD/PharmD).
• 5+ years of pharmacometrics and Clinical Pharmacology experience with rising impact.
• Expertise in data wrangling, visualization, and PMx modeling.
• Proficiency with R, NONMEM, Monolix, Pumas, MATLAB, Python or Julia.
• Knowledge of QSP and PBPK is a plus.

Responsibilities

• Lead development of the MIDD strategy and PMx plan for assets.
• Integrate quantitative disciplines to create a coherent data strategy.
• Plan, execute, interpret, and report PMx analyses for CSRs and regulatory questions.
• Translate modeling results into actionable recommendations for asset strategy.
• Serve as MIDD subject matter expert and influence regulatory strategy.
• Advance PMx infrastructure, tools, and ways of working.
• Mentor junior scientists in PMx and MIDD.
• Collaborate with internal/external experts to advance methodologies.

Skills

PMx analysis

Cross-functional leadership

Quantitative data analysis

Scientific writing

Stakeholder communication

Education

MS in pharmacometrics or related

PhD in quantitative field or PharmD

Tools

R

NONMEM

Monolix

Pumas

MATLAB

Python

Julia

Job description

Position Summary

Leads the development and implementation of the Model-Informed Drug Development (MIDD) strategy for drugs and other therapeutic agents in clinical development, in partnership with Clinical Pharmacology (CP) and other quantitative functions. This role places quantitative evidence at the center of development and regulatory decision-making. MIDD advances drug development by integrating diverse data through pharmacometric (PMx) models to inform development decisions and regulatory assessments. Model-Based Meta-Analysis (MBMA) provides a quantitative assessment of competitors and comparators to further refine asset strategy. MIDD informs dose and regimen selection, clinical study hypotheses, and the overall clinical data package supporting regulatory assessment of clinical pharmacology and benefit-risk. PMx analyses may also influence regulatory approval decisions and, in some cases, serve as a primary basis for approval.

Key Responsibilities

• Partner with the Clinical Pharmacology lead to develop the MIDD strategy and define the PMx plan for assigned assets.
• Lead integration across quantitative disciplines to develop and execute a coherent modeling and data strategy.
• Lead the planning, execution, interpretation, and reporting of formal PMx analyses supporting clinical study reports (CSRs), health authority submissions, and responses to regulatory questions.
• Translate complex modeling results into clear, actionable recommendations that inform asset strategy, development plans, and governance decisions.
• Serve as the MIDD subject matter expert, partnering with Clinical Pharmacology and other quantitative functions to influence development decisions for therapeutic agents.
• Advance PMx infrastructure, tools, methodologies, and ways of working.
• Lead PMx and cross-functional initiatives that strengthen quantitative decision-making across development programs.
• Provide scientific direction and oversight for PMx analyses conducted by external vendors.
• Represent the MIDD strategy and provide subject matter expertise in interactions with health authorities, helping to inform regulatory strategy.
• Collaborate with internal and external subject matter experts to advance MIDD methodologies and capabilities and introduce innovative quantitative approaches into development programs.
• Provide scientific guidance and mentorship to junior scientists in PMx and MIDD.

Qualifications & Experience

• Advanced degree in a relevant scientific or quantitative field, such as an MS, PhD, or PharmD.
• 5+ years of relevant experience with demonstrated progression in pharmacometrics and Clinical Pharmacology knowledge and increasing scientific impact.
• Demonstrated expertise in quantitative data analysis, data wrangling and transformation, visualization, population pharmacokinetic (PPK) modeling, and exposure-response (E-R) modeling.
• Proficiency with relevant modeling and programming tools, such as R, NONMEM, Monolix, Pumas, MATLAB, Python, and/or Julia.
• Working knowledge of the drug development process and the application of quantitative evidence to development and regulatory decision-making.
• Experience with mechanistic modeling approaches, such as Quantitative Systems Pharmacology (QSP) and Physiologically Based Pharmacokinetic (PBPK) modeling, is preferred.
• In-depth knowledge of current practices, methodologies, and emerging issues in pharmacometrics and Clinical Pharmacology, with a demonstrated interest in advancing the field.
• Strong written and verbal communication skills, with the ability to influence stakeholders and deliver compelling scientific presentations.
• Demonstrated ability to translate complex modeling results into clear recommendations that influence cross-functional decisions.
• Proven ability to drive scientific impact in a dynamic, collaborative, and team-oriented environment.

#LI-Hybrid

#LI-Hybrid

Compensation Overview

• Cambridge Crossing: $209,250 - $253,565

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits

• Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).
• U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.
• Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.
• Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs.
• Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.
• U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

How We Work

• Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design.
• The model assigned to this role is based on its core responsibilities.
• Learn more at https://careers.bms.com/ways-of-working.

Supporting People with Disabilities

• BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles.
• Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer.
• If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail].
• Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

• BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
• For roles based in Los Angeles County only: If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/
• For roles based in Washington State only: If you live in or expect to work from Washington State if hired for this position, please visit this page for important information about the Washington Fair Chance Act.

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. If this posting is missing required information required by local law or incorrect, contact BMS at [e-mail] the Job Title and Requisition number.

We’re creating innovative medicines for patients fighting serious diseases. We’re also nurturing our own diverse team with inspiring work and challenging career options. No matter the role, each one of us makes a contribution. And that makes all the difference.