Associate Director, Precision Medicine

Bristol-Myers Squibb Company; Cambridge (MA); On-site; USD 209,000 - 254,000; Full time

Benefits offered by this job

Wellbeing support

Retirement and financial protection

Insurance offerings

Flexible Time Off

Job summary

Bristol Myers Squibb in Cambridge, MA seeks an Associate Director, Precision Medicine to lead the Model-Informed Drug Development strategy for clinical programs. You will partner with Clinical Pharmacology and other quantitative teams to integrate PMx analyses into development decisions and regulatory strategies.

The role requires an advanced degree (MS/PhD/PharmD) and 5+ years in pharmacometrics, with proficiency in R, NONMEM, Monolix, Pumas, MATLAB, Python or Julia.

Qualifications

• Advanced degree in a relevant scientific or quantitative field (MS/PhD/PharmD).
• 5+ years of pharmacometrics and Clinical Pharmacology experience with increasing impact.
• Proficiency in quantitative data analysis, data wrangling, visualization, PPK and exposure–response modeling.

Responsibilities

• Partner with the Clinical Pharmacology lead to develop the MIDD strategy and define the PMx plan for assigned assets.
• Lead integration across quantitative disciplines to develop and execute a coherent modeling and data strategy.
• Lead PMx analyses supporting CSRs, health authority submissions, and responses to regulatory questions.
• Translate complex modeling results into clear, actionable recommendations for asset strategy and governance decisions.
• Represent the MIDD strategy and provide SME input in interactions with health authorities.

Skills

Pharmacometric modeling

MIDD strategy

PMx analyses

Data visualization

Programming

Education

MS/PhD/PharmD in relevant field

Tools

R

NONMEM

Monolix

Pumas

MATLAB

Python

Julia

Job description

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Position Summary

Leads the development and implementation of the Model-Informed Drug Development (MIDD) strategy for drugs and other therapeutic agents in clinical development, in partnership with Clinical Pharmacology (CP) and other quantitative functions. This role places quantitative evidence at the center of development and regulatory decision-making.

MIDD advances drug development by integrating diverse data through pharmacometric (PMx) models to inform development decisions and regulatory assessments. Model-Based Meta-Analysis (MBMA) provides a quantitative assessment of competitors and comparators to further refine asset strategy. MIDD informs dose and regimen selection, clinical study hypotheses, and the overall clinical data package supporting regulatory assessment of clinical pharmacology and benefit-risk. PMx analyses may also influence regulatory approval decisions and, in some cases, serve as a primary basis for approval.

Key Responsibilities

• Partner with the Clinical Pharmacology lead to develop the MIDD strategy and define the PMx plan for assigned assets.
• Lead integration across quantitative disciplines to develop and execute a coherent modeling and data strategy.
• Lead the planning, execution, interpretation, and reporting of formal PMx analyses supporting clinical study reports (CSRs), health authority submissions, and responses to regulatory questions.
• Translate complex modeling results into clear, actionable recommendations that inform asset strategy, development plans, and governance decisions.
• Serve as the MIDD subject matter expert, partnering with Clinical Pharmacology and other quantitative functions to influence development decisions for therapeutic agents.
• Advance PMx infrastructure, tools, methodologies, and ways of working.
• Lead PMx and cross-functional initiatives that strengthen quantitative decision-making across development programs.
• Provide scientific direction and oversight for PMx analyses conducted by external vendors.
• Represent the MIDD strategy and provide subject matter expertise in interactions with health authorities, helping to inform regulatory strategy.
• Collaborate with internal and external subject matter experts to advance MIDD methodologies and capabilities and introduce innovative quantitative approaches into development programs.
• Provide scientific guidance and mentorship to junior scientists in PMx and MIDD.

Qualifications & Experience

• Advanced degree in a relevant scientific or quantitative field, such as an MS, PhD, or PharmD.
• 5+ years of relevant experience with demonstrated progression in pharmacometrics and Clinical Pharmacology knowledge and increasing scientific impact.
• Demonstrated expertise in quantitative data analysis, data wrangling and transformation, visualization, population pharmacokinetic (PPK) modeling, and exposure-response (E-R) modeling.
• Proficiency with relevant modeling and programming tools, such as R, NONMEM, Monolix, Pumas, MATLAB, Python, and/or Julia.
• Working knowledge of the drug development process and the application of quantitative evidence to development and regulatory decision-making.
• Experience with mechanistic modeling approaches, such as Quantitative Systems Pharmacology (QSP) and Physiologically Based Pharmacokinetic (PBPK) modeling, is preferred.
• In-depth knowledge of current practices, methodologies, and emerging issues in pharmacometrics and Clinical Pharmacology, with a demonstrated interest in advancing the field.
• Strong written and verbal communication skills, with the ability to influence stakeholders and deliver compelling scientific presentations.
• Demonstrated ability to translate complex modeling results into clear recommendations that influence cross-functional decisions.
• Proven ability to drive scientific impact in a dynamic, collaborative, and team-oriented environment.

#LI-Hybrid

Compensation Overview:

Cambridge Crossing: $209,250 - $253,565

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits:

• Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).
• U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.
• Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.
• Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.
• U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

How We Work

Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail] . Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

For roles based in Los Angeles County only: If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

For roles based in Washington State only: If you live in or expect to work from Washington State if hired for this position, please visit this page for important information about the Washington Fair Chance Act.

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection .

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If this posting is missing required information required by local law or incorrect, contact BMS at [e-mail] with the Job Title and Requisition number. Do not send application-related inquiries to this email. To check your application status, please login to your Candidate Home Account.

R1608260 : Associate Director, Precision Medicine