Associate Director, Oncology Intelligence & Real‑World Evidence

AstraZeneca plc; Cambridge (MA); Hybrid; USD 145,000 - 184,000; Full time

Benefits offered by this job

401(k) plan

Health benefits

Paid vacation

Job summary

AstraZeneca plc is seeking a senior scientific leader in Hematology/Oncology analytics to turn complex clinical and real‑world data into decision‑ready evidence. You will partner with Global Product Teams to guide Phase 3 investments, trial design, and patient access decisions.

You will build and validate multimodal patient models, focusing on reproducible analyses and external control arms, shaping portfolio strategy and evidence generation across indications.

Qualifications

• PhD or equivalent in a quantitative discipline such as epidemiology, biostatistics, computational biology, machine learning, or health data science.
• Strong methodological foundation in causal inference and observational study design.
• Hands-on experience with ML and multimodal modeling using real-world and clinical data.

Responsibilities

• Identify and prioritize evidence needs across the product lifecycle for Phase 3 decisions.
• Apply ML and causal inference to deliver robust answers on patient stratification and external control arms.
• Develop multimodal patient models integrating clinical, genomic, imaging, and RWD data.
• Translate data into actionable insights for development, regulatory, and HTA submissions.
• Collaborate to bring new tools and approaches into evidence generation pipelines.
• Coordinate with Translational Science and Clinical Development for signals like digital endpoints and biomarkers.

Skills

Causal inference expertise

Multimodal modeling

External control arms

Regulatory/HTA familiarity

Evidence generation

Education

PhD or equivalent in quantitative field

Tools

Python

R

SQL

Cloud platforms

Job description

AstraZeneca plc is seeking a senior scientific leader in Hematology/Oncology analytics to turn complex clinical and real‑world data into decision‑ready evidence. You will partner with Global Product Teams to guide Phase 3 investments, trial design, and patient access decisions.

You will build and validate multimodal patient models, focusing on reproducible analyses and external control arms, shaping portfolio strategy and evidence generation across indications.