Associate Director, Oncology Clinical Intelligence and Real World Evidence

AstraZeneca; Gaithersburg (MD); Hybrid; USD 122,000 - 160,000; Full time

Benefits offered by this job

Short-term incentive bonus

Equity-based long-term incentive

401(k) plan

Paid vacation and holidays

Health benefits

Job summary

AstraZeneca is seeking a technical specialist in clinical intelligence and real-world evidence to translate complex data into decision-ready insights for Hematology/Oncology. The role partners with Global Product Teams to shape evidence generation strategies and advance Phase 3 investments and patient access.

You will build multimodal patient models, work with external control arms, and apply causal inference and ML within regulated HTA frameworks, leveraging Python, R, and SQL in cloud

Qualifications

• Advanced degree (PhD or equivalent) in a quantitative field.
• Strong causal inference methods and observational study design.
• Hands-on ML and multimodal modeling experience.
• Experience with external control arms or trial simulators.
• Knowledge of regulatory/HTA evidentiary standards.
• Proficiency in Python, R, and SQL; cloud analytics familiarity.

Responsibilities

• Prioritize evidence needs across hematology/oncology product lifecycle.
• Apply ML and causal inference to patient stratification.
• Build multimodal patient models from diverse data.
• Produce decision-ready insights for development and access.
• Collaborate with platform teams to enable new tools.
• Bridge strategic evidence with technical delivery.

Skills

Causal inference

Multimodal modeling

Observational study design

Machine learning

External control arms

Regulatory/HTA

Education

PhD or equivalent in a quantitative field

Tools

Python

R

SQL

Job description

WHY JOIN US?

At AstraZeneca, we are dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. With an ambitious goal of delivering 20 new medicines by 2030, there is no better place to make a difference in medicine, for patients, and in society.

Join us on this exciting journey to pioneer the future of healthcare. Our inclusive culture champions diversity and collaboration, and we are always committed to lifelong learning, growth, and development. As part of our team, you'll contribute to groundbreaking advancements that will shape a healthier future for people everywhere. Be a catalyst for change at AstraZeneca, where your work will have a real impact on improving people's lives.

Recognizing the importance of individualized flexibility, our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week. Our head office is purposely designed with collaboration in mind, providing space where teams can come together to strategize, brainstorm and connect on key projects.

Introduction to role:

Are you ready to turn complex clinical and real-world data into evidence that shapes pivotal decisions in Hematology/Oncology? Do you want your analytics to directly influence Phase 3 investments, trial design, and patient access?

In this role, you will operate where evidence generation meets hands‑on analytics, partnering with stakeholders to pinpoint the highest‑value evidence gaps and leading the delivery that closes them. You will move seamlessly from portfolio‑level prioritization with Global Product Teams to building rigorous multimodal patient models or external control arm analyses that inform development and access.

Hematology is growing rapidly. As the technical specialist for clinical intelligence and real‑world evidence, you will translate complex data into decision‑ready insights, build persistent intelligence that compounds across use cases, and help steer how the portfolio advances for patients.

Accountabilities:

• Evidence Gap Prioritization: Partner with Hematology/Oncology stakeholders and Global Product Teams to identify and prioritize evidence needs across the product lifecycle, including Phase 3 investment decisions, subpopulation discovery, and trial design.
• AI and Causal Inference Analytics: Apply machine learning and causal inference to deliver robust answers on patient stratification, external control arm construction, prognostic risk adjustment, and treatment effect heterogeneity, ensuring analyses meet regulatory and HTA expectations.
• Multimodal Patient Models: Deliver and validate patient-level models that integrate clinical, genomic, imaging, and real‑world data for deployment in clinical trials or routine care, with emphasis on reproducibility and rigorous validation.
• Decision‑Ready Insights: Turn internal and competitor trial data, alongside real‑world data, into clear insight on standard of care, patient pathways, benchmarking, and unmet need to sharpen development and access strategies.
• Platform Enablement: Work with platform and tooling teams to bring new tools, agents, and experimental approaches into evidence generation, and build Hematology‑specific intelligence that persists within the Phase 3 Investment Decision Intelligence Foundation.
• Cross‑Functional Collaboration: Connect strategic evidence needs with technical delivery, aligning outputs to development, regulatory, and access milestones; collaborate with Translational Science and Clinical Development to incorporate novel signals such as digital endpoints, pathology AI, and biomarker panels.

Essential Skills/Experience:

• Advanced degree (PhD or equivalent) in a quantitative discipline - epidemiology, biostatistics, computational biology, machine learning, health data science, or a related field.
• Strong methodological foundation in causal inference and observational study design, including propensity score methods, instrumental variables, target trial emulation, and comparative effectiveness research.
• Hands‑on experience with machine learning and multimodal modeling, including supervised and unsupervised methods, deep learning for imaging or molecular data, and integration of heterogeneous data types into patient-level models.
• Experience building or contributing to external control arms, trial simulators, or prognostic models using real‑world and/or clinical trial data.
• Understanding of regulatory and health technology assessment (HTA) evidence standards, with the ability to design analyses that meet the evidentiary bar for submissions and payer engagement.
• Proficiency in Python, R, and SQL, and familiarity with cloud‑based analytics environments.

Desirable Skills/Experience:

• Domain expertise in hematology or oncology and familiarity with disease‑specific endpoints, pathways, and standards of care.
• Track record of influencing cross‑functional strategy with evidence, engaging product and clinical leaders to drive decisions.
• Experience deploying analytics into clinical trial operations, submissions, or payer engagements.
• Publications, conference presentations, or open‑source contributions in causal inference, multimodal modeling, or real‑world evidence.
• Hands‑on experience with cloud platforms and MLOps practices to scale models and pipelines.
• Experience integrating digital endpoints, pathology AI, or biomarker panels into evidence strategies.
• Ability to design reusable data and model assets that generalize across indications and studies.

#LI-Hybrid

The annual base pay for this position ranges from $122,121.60 - $160,284.60 USD. Base pay offered may vary depending on multiple individualized factors, including market location, job‑related knowledge, skills, and experience.

• short‑term incentive bonus opportunity
• eligibility to participate in our equity‑based long‑term incentive program
• qualified retirement program [401(k) plan]
• paid vacation and holidays
• paid leaves
• health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans

Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment.

If hired, employee will be in an “at‑will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted
01-Nov-2026

Closing Date
12-Nov-2026

AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing [e-mail].

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.