Associate Director, Data Science, Functional Genomics

Jobtailor; California (MO); On-site; USD 180,000 - 240,000; Full time

Job summary

Jobtailor is seeking a senior leader to design and build scalable computational analytics for pooled, arrayed, single-cell, and optical CRISPR screens. You will guide QC pipelines, library design, and longitudinal readouts, while integrating functional genomics with transcriptomics and proteomics data.

You will apply ML/LLM-powered methods, mentor scientists, and drive reproducible research and FAIR data infrastructure across collaborations with scientists and engineers.

Qualifications

• MS in computational biology, biostatistics, biophysics, mathematics, genetics/genomics, computer science or related STEM.
• Minimum 8 years of experience analyzing large-scale NGS and functional genomics datasets.
• Experience with computational analysis, algorithm development, and biological interpretation of large-scale NGS datasets.
• Proven track record applying machine learning to single-cell RNA sequencing data.
• Experience with experimental design, statistical hypothesis testing, and integrating multiple omics data sources.
• Proficiency in R or Python; experience with Git.
• Familiarity with TCGA, DepMap, CCLE, CPTAC.
• Experience with AWS and Linux environments.
• Excellent communication and mentoring skills.
• Up to 10% travel.

Responsibilities

• Lead design and build of scalable analytics frameworks for CRISPR screens.
• Develop QC pipelines and longitudinal readout analysis.
• Mentor scientists and set technical direction for analytics team.
• Drive reproducible research standards and FAIR data practices.
• Collaborate with experimentalists, software engineers, and external partners.

Skills

Machine Learning

R/Python

Single-Cell RNA-Seq

Data Integration

Team Leadership

Education

MS in Computational Biology

PhD preferred

Tools

AWS Cloud Computing

Linux

Git

R Shiny

Job description

• Lead the design and build of scalable computational analytics frameworks for pooled, arrayed, single-cell, and optical CRISPR screens
• Develop QC pipelines, library design methods, and longitudinal readout analysis
• Invent and scale computational methods for single-cell perturbation screening, cellular barcoding, and lineage tracing
• Build image analysis pipelines for high-content and optical CRISPR screens
• Integrate functional genomics and imaging results with transcriptomics and proteomics datasets
• Build multi-evidence target prioritization packages across stages of drug discovery
• Apply AI and ML, including LLM-powered agentic workflows and network-based methods, to triage targets and synthesize biological evidence
• Lead and mentor scientists and set the technical direction for functional genomics analytics
• Drive standards for reproducible research and FAIR data infrastructure
• Collaborate with experimental scientists, software engineers, and external partners
• Support Therapeutic Area target identification

Requirements

• MS in computational biology, bioinformatics, biostatistics, biophysics, mathematics, statistics, genetics/genomics, computer science or a related STEM discipline
• Minimum of 8 years of relevant professional experience, including hands-on experience analyzing large-scale NGS and functional genomics datasets
• Experience with computational analysis, algorithm development, and biological interpretation of large-scale NGS and functional genomics datasets
• Proven track record applying machine learning to single-cell RNA sequencing data
• Experience with experimental design of biological assays, statistical hypothesis testing, and integrating multiple omics data sources
• Proficiency in R or Python
• Experience with version control environments such as Git
• Familiarity with The Cancer Genome Atlas, Dependency Map, Cancer Cell Line Encyclopedia, and Clinical Proteomic Tumor Analysis Consortium
• Experience with AWS cloud computing infrastructure and Linux environments
• Excellent oral and written communication skills
• Up to 10% travel required
• Preferred: Ph.D. in a related STEM field with 4+ years of professional experience
• Preferred: Postdoctoral or relevant industry experience, analytics team leadership, and scientist mentoring
• Preferred: Functional genomics data, CRISPR screen hit-calling frameworks, and library design interpretation
• Preferred: Optical pooled CRISPR screening image analysis pipelines
• Preferred: Deep learning for image-based phenotypic profiling and cell classification
• Preferred: Disease biology and immunology knowledge
• Preferred: Network-based analysis frameworks or transfer learning techniques
• Preferred: LLM-powered systems or AI tools for biological data interrogation
• Preferred: Interactive data visualization tools such as R Shiny
• Preferred: First-author publications or released tools demonstrating novel functional genomics methods

Core Competencies

Demonstrates expertise in computational biology and bioinformatics, with a strong focus on developing scalable analytics frameworks and integrating multi-omics data. Proficient in machine learning applications for biological data analysis and experienced in leading teams in functional genomics research.

Highest-signal resume keywords

• Computational Analysis
• Machine Learning Application
• R or Python Proficiency
• Large-Scale NGS Data Analysis
• Functional Genomics Expertise

Hard Skills

• Computational Biology
• Bioinformatics
• Algorithm Development
• Statistical Hypothesis Testing
• Single-Cell RNA Sequencing
• Library Design Methods
• Image Analysis Pipelines
• Data Integration
• Deep Learning
• Cell Classification

Soft Skills

• Excellent Communication Skills
• Team Leadership
• Mentoring

Industry Keywords

• CRISPR Screening
• Functional Genomics
• NGS Datasets
• Multi-Omics Data
• The Cancer Genome Atlas
• Dependency Map
• Cancer Cell Line Encyclopedia
• Clinical Proteomic Tumor Analysis Consortium

Tools & Technologies

• AWS Cloud Computing
• Linux Environments
• Version Control (Git)
• R Shiny
• AI Tools