Principal Scientist, Computational Biology

Scorpion Therapeutics; Cambridge (MA); On-site; USD 167,000 - 202,000; Full time

Job summary

Scorpion Therapeutics is seeking a senior computational biologist to lead research on multimodal biological profiling data in Cambridge, MA. The role focuses on developing integrative analyses and applying ML to connect perturbation readouts with disease states.

You will collaborate with industry and academic partners, presenting findings and guiding follow-up actions in team settings. A PhD with extensive post-graduate experience and strong Python/R skills are required.

Qualifications

• PhD in a quantitative field and 5+ years post-graduate experience.
• Advanced hands-on knowledge of R or Python for computational research.

Responsibilities

• Perform computational research and integrative analyses on multimodal biological profiling datasets to support early pipeline programs.
• Apply machine learning and advanced computational approaches to compare high-dimensional perturbation readouts to disease states and nominate new targets.
• Collaborate with external partners (industry, academia, NIH AMP) on novel computational and experimental approaches.
• Communicate findings and recommended actions in 1:1s, seminars, and team meetings.

Skills

R

Python

Computational research

Education

PhD in quantitative field

Job description

Responsibilities

• Perform computational research and integrative analyses on multimodal biological profiling datasets (transcriptomic, proteomics, single-cell omics, spatial profiling) to support early pipeline programs.
• Apply machine learning and advanced computational/statistical approaches to compare high-dimensional perturbation readouts (CRISPR screens, perturb-seq, cellular imaging) to patient-defined disease states; nominate and validate new targets for Neuro, Cardiovascular, and Autoimmune indications.
• Collaborate with external partners (industry, academia, pre-competitive collaborations such as NIH AMP) on novel computational and experimental approaches.
• Communicate findings and recommend follow-up actions (1:1s, seminars, team meetings).

Basic Qualifications

• PhD in a quantitative field (computational biology, computational genomics/genetics, computer science, statistics, mathematics, or related) and 5+ years post-graduate experience.
• Advanced hands-on knowledge of R or Python for computational and reproducible research.

Preferred Qualifications

• 5+ years post-graduate computational biology research experience (biopharma preferred) with publications/track record.
• Experience integrating high-dimensional multi-omics, single-cell (CITE-seq, scATAC-seq, perturb-seq), and/or spatial profiling.
• Strong statistical and ML skills (e.g., single-cell foundation models).
• Human disease biology background, especially autoimmune diseases.
• Experience with computer vision for cellular imaging; AI agent tools (e.g., Claude coding); strong self-learning and oral/written communication.

Location

Cambridge, MA (no fully remote option)

Compensation Overview

$166,770–$202,086