Associate Director, Data Science

U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.; Cambridge (MA); Hybrid; USD 160,000 - 298,000; Full time

Benefits offered by this job

Comprehensive benefits

401(k) with company match

Generous paid time off

Hybrid work model

On-site Cambridge

Job summary

Novartis Institutes for BioMedical Research, Inc. is seeking an experienced Data Science leader to advance data-driven drug discovery and development in Cambridge, MA.

You will integrate AI, mechanistic modelling, and MIDD to support decision-making across discovery to clinical development. The role requires collaboration across PKS M&S, Translational Medicine, and Data & Digital teams, with a hybrid on-site schedule and a salary range that reflects market factors and experience.

Qualifications

• Advanced degree in life sciences or quantitative discipline.
• PhD with 5+ years or MSc with 8+ years of relevant experience in drug discovery or development.
• Strong expertise in machine learning, statistics, and data science methods.
• Demonstrated experience applying reproducible data science approaches to drug discovery or development.
• Experience combining mechanistic modelling and data-driven approaches is strongly preferred.
• Strong understanding of ADME, PK/PD, and/or translational modelling concepts.
• Proficiency in Python and/or R, including software development best practices (version control, testing, documentation).
• Experience with machine learning libraries such as scikit-learn, PyTorch, or Keras.
• Strong data visualization and exploratory data analysis skills.
• Ability to translate complex analytical concepts into clear, actionable insights.
• Strong collaboration and communication skills across multidisciplinary teams.
• Fluency in English (oral and written).

Responsibilities

• Shape and advance AI-driven MIDD by integrating mechanistic modelling and machine learning to bridge biology and clinical outcomes.
• Design and implement hybrid modelling pipelines where mechanistic simulations generate features for machine learning models.
• Translate model-derived biomarkers and mechanistic states into clinically relevant predictions and decision-support tools.
• Drive scientifically grounded AI approaches that enhance mechanistic understanding, ensuring rigor, interpretability, and robustness.
• Develop scalable, reproducible workflows integrating data science, mechanistic modelling, and in-house tools.
• Define and implement project-specific in silico modelling and data strategies aligned with key decision questions.
• Apply and advance currently available data mining and advanced analytics to link molecular structure, ADME properties, and pharmacological outcomes across modalities.
• Drive adoption and effective use of in silico models, tools, and data to accelerate decision-making.
• Collaborate with PKS, Translational Medicine, and Data & Digital teams to integrate diverse datasets (preclinical, clinical, external).
• Contribute to translational programs across disease areas and communicate modelling insights to influence decision-making.
• Stay current with advances in AI/ML and their application to ADME, PK/PD, and drug discovery and development, and proactively evaluate and bring appropriate innovation into practice to improve efficiency and scientific impact.

Skills

Artificial Intelligence

Biostatistics

Business Value Creation

Change Management

Curious Mindset

Data Governance

Data Literacy

Data Quality

Data Science

Data Visualization

Deep Learning

Graph Algorithms

Learning Agility

Machine Learning

Machine Learning Algorithms

Nlp (Neuro-Linguistic Programming) And

Genai

Organization Awareness

Pandas (Python)

Python

R

Sql

Stakeholder Engagement

Statistical Analysis

Time Series Analysis

Education

PhD or MSc in life sciences or quantitative discipline

Tools

scikit-learn

PyTorch

Keras

Python

R

Pandas

Job description

Job Description Summary #LI-Hybrid Internal Title: Associate Director Location: Cambridge, MA

Novartis is a leader in data science and model-informed drug development. We are seeking an experienced Data Science leader to advance data-driven drug discovery and development by integrating advanced analytics, machine learning, and mechanistic modelling approaches. In this role, you will partner with Pharmacokinetic Sciences (PKS) Modeling & Simulation (M&S), Translational Medicine, and multidisciplinary project teams to transform large-scale experimental datasets into actionable insights. You will develop and apply hybrid approaches that combine machine learning with mechanistic modelling (e.g., PK/PD, QSP) to support decision-making from discovery through clinical development. You will contribute to departmental strategy, drive innovation in AI-augmented modelling approaches, and ensure the proactive use of data science and in silico methods to guide compound progression, prioritization, and clinical decision-making. This role reports to the Head of Data Science in the PKS M&S team within Translational Medicine in Biomedical Research.

Job Description Key responsibilities

• Shape and advance AI-driven MIDD by integrating mechanistic modelling and machine learning to bridge biology and clinical outcomes.
• Design and implement hybrid modelling pipelines where mechanistic simulations generate features for machine learning models.
• Translate model-derived biomarkers and mechanistic states into clinically relevant predictions and decision-support tools.
• Drive scientifically grounded AI approaches that enhance mechanistic understanding, ensuring rigor, interpretability, and robustness.
• Develop scalable, reproducible workflows integrating data science, mechanistic modelling, and in-house tools.
• Define and implement project-specific in silico modelling and data strategies aligned with key decision questions.
• Apply and advance currently available data mining and advanced analytics to link molecular structure, ADME properties, and pharmacological outcomes across modalities.
• Drive adoption and effective use of in silico models, tools, and data to accelerate decision-making.
• Collaborate with PKS, Translational Medicine, and Data & Digital teams to integrate diverse datasets (preclinical, clinical, external).
• Contribute to translational programs across disease areas and communicate modelling insights to influence decision-making.
• Stay current with advances in AI/ML and their application to ADME, PK/PD, and drug discovery and development, and proactively evaluate and bring appropriate innovation into practice to improve efficiency and scientific impact.

Essential requirements

• Advanced degree in life sciences or quantitative discipline (e.g., data science, computational biology, pharmacometrics, bioinformatics, computational chemistry, biomedical engineering or related field).
• PhD with 5+ years or MSc with 8+ years of relevant experience in drug discovery or development.
• Strong expertise in machine learning, statistics, and data science methods.
• Demonstrated experience applying reproducible data science approaches to drug discovery or development.
• Experience combining mechanistic modelling and data-driven approaches is strongly preferred.
• Strong understanding of ADME, PK/PD, and/or translational modelling concepts.
• Proficiency in Python and/or R, including software development best practices (version control, testing, documentation).
• Experience with machine learning libraries such as scikit-learn, PyTorch, or Keras.
• Strong data visualization and exploratory data analysis skills.
• Ability to translate complex analytical concepts into clear, actionable insights.
• Strong collaboration and communication skills across multidisciplinary teams.
• Fluency in English (oral and written).

This is a hybrid role that requires a balance of in-person and virtual working, with an average of 12 days a month on site in Cambridge, MA.

The salary for this position is expected to range between $160,300 and $297,700 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

Skills Desired

• Artificial Intelligence (AI)
• Biostatistics
• Business Value Creation
• Change Management
• Curious Mindset
• Data Governance
• Data Literacy
• Data Quality
• Data Science
• Data Visualization
• Deep Learning
• Graph Algorithms
• Learning Agility
• Machine Learning (ML)
• Machine Learning Algorithms
• Nlp (Neuro-Linguistic Programming) And Genai
• Organization Awareness
• Pandas (Python)
• Python (Programming Language)
• R (Programming Language)
• Sql (Structured Query Language)
• Stakeholder Engagement
• Statistical Analysis
• Time Series Analysis

Salary Range $160,300.00 - $297,700.00

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [e-mail] or call [phone] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

In the context of China Cross-Border Data Transfer (CBDT) policy, if you need to apply for a position in China, please go to the local Recruiting System TaleNov.