Associate Director, Clinical Operations

Revolution Medicines; San Francisco (CA); On-site; USD 186,000 - 233,000; Full time

Job summary

Revolution Medicines is seeking an Associate Director, Clinical Operations to lead CRO oversight and manage global phase 1-3 trials in oncology. You will ensure GCP, FDA and ICH compliance, align CDP timelines and budgets, and deploy clinical operations staff across programs.

This role requires 11+ years in clinical operations, strong vendor management, leadership, and excellent communication. Onsite at Redwood City, CA with travel up to 25% and a base salary of $186k–$233k.

Qualifications

• RN or Bachelor’s or Master’s degree in biological sciences or health-related field required.
• 11+ years direct Clinical Operations experience in the pharmaceutical or biotech industry.
• Minimum of 5 years of project and first-line management experience.
• Experience in leading and managing global phase 1-3 clinical trials within timelines, resources, and budgets.
• Strong working knowledge of FDA Regulations, ICH Guidelines, and GCP.
• Experience with vendor management and CRO oversight.
• Ability to perform complex analysis, draw relevant conclusions, and implement solutions.
• Able to adapt to fast-paced environment with shifting priorities.
• Excellent interpersonal, verbal, and written communication skills.

Responsibilities

• Oversee CROs and selected vendors to meet program milestones on budget and timeline.
• Lead and develop Clinical Operations staff (PMs/PTMs/CTAs and consultants).
• Partner with Clinical Development, Regulatory, QA, Finance and Legal to achieve study goals.
• Ensure trials remain inspection-ready throughout the lifecycle of each program.
• Improve processes and contingency plans to strengthen trial management.

Skills

Clinical Operations

Vendor management

CRO oversight

Project leadership

Regulatory knowledge

Data analysis

Multi-tasking

Communication skills

MS Office

Travel readiness

Education

RN or Bachelor’s/Master’s in biological sciences

Tools

MS Project

Smartsheet

eTMF

EDC

IRT

CTMS

Job description

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity:

This is a unique opportunity for a Clinical Operations Professional who has innate leadership and organizational skills, technical expertise in clinical oncology drug development in an industry setting, and experience in overseeing clinical trials. As an Associate Director, you will be responsible for the Contract Research Organization (CRO) oversight, execution, and management of Revolution Medicines (RevMed) clinical trials.

Responsibilities:

• Adhere to Clinical Standard Operating Procedures (SOP) and Good Clinical Practice (GCP) and International Conference on Harmonization (ICH) Guidelines.
• Oversee the successful management of all aspects of clinical trials within timelines and designated program budgets.
• Strategic thought partner on the development, management, and execution of the Clinical Development Plan (CDP) for assigned clinical programs which includes timelines, budget, and resource requirements. Ability to identify critical path activities and articulate and mitigate risks to clinical trial conduct.
• Responsible for successful planning and deployment of Clinical Operations staff (potentially including Clinical Program Managers/Clinical Trial Managers/Clinical Trial Assistants, and consultants) for project and non-project related tasks.
• Lead line management responsibilities that include hiring, performance management, career development, and mentorship.
• Manage/oversee CROs and selected study vendors; ensuring all vendors strive to achieve the predetermined program milestones according to budget and timeline, as well as evaluate vendor performance using metrics and KPIs.
• Lead team meetings and collaborate with other functional groups within the company (e.g., Clinical Development, Regulatory, QA, Finance, Legal, etc.) to achieve clinical study goals.
• Ensure clinical trials maintain an inspection readiness state throughout the lifecycle of the trial.
• Oversee the improvement of processes that will impact clinical trial management and deliverables including contingency plans by maintaining a highly effective Clinical Operations team and building strong relationships with functional leaders.

Required Skills, Experience and Education:

• RN or Bachelor’s or Master’s degree in biological sciences or health-related field required.
• 11+ years direct Clinical Operations experience in the pharmaceutical or biotech industry. Relevant indirect experiences may also meet the requirement.
• Minimum of 5 years of project and first-line management experience.
• Experience in leading and managing global phase 1-3 clinical trials within designated timelines, resources, and budgets.
• Strong working knowledge of FDA Regulations, ICH Guidelines, and GCP.
• Experience with vendor management and CRO oversight.
• Ability to perform complex analysis, draw relevant conclusions, and implement appropriate solutions.
• Ability to pivot, be solution-oriented with consideration to long-term impact on clinical trials, responsibilities, and inspection-readiness.
• Strong analytical, negotiation, and persuasion skills.
• Ability to deal with time demands, incomplete information, or unexpected events.
• Outstanding organizational skills with the ability to multi-task and prioritize.
• Excellent interpersonal, verbal, and written communication skills.
• Decision-making skills.
• Comfortable in a fast-paced company environment and able to adjust workload based upon changing priorities.
• Demonstrate proficiency in Microsoft Office Suite (Outlook, MS Word, Excel, PowerPoint); MS Project and/or Smartsheet a plus.
• Travel may be required (~25%).

Preferred Skills:

• Proven success working with vendor systems/portals (e.g., eTMF, EDC, IRT, CTMS).
• Oncology experience, early and/or late stage, strongly preferred.
• Knowledge and/or familiarity with Ex-US region(s) clinical trial operations.
• Experience in working with cooperative group studies and investigator sponsored trials preferred.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Base Pay Salary Range

$186,000 - $233,000 USD

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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