Associate Director, Chemical Engineering — DS Scale-Up

nurix; Brisbane (CA); On-site; USD 180,000 - 240,000; Full time

Job summary

Nurix Therapeutics is seeking an Associate Director, Chemical Engineering to lead end-to-end chemical engineering support for bexobrutideg DS from late-stage development through commercial launch, including CDMO oversight and tech transfer.

Reporting to the Director, Chemical Development, you will drive scalable routes, supervise CDMO operations, ensure cGMP compliance, and collaborate across CMC, QA, and supply chain to support timely manufacturing and regulatory readiness.

Qualifications

• Ph.D. in chemical engineering, or related field with at least 5 years (M.S. with 10 years or B.S. with 15 years) of industrial, late‑phase, small‑molecule drug substance development experience
• GMP drug substance manufacturing, characterization, process development, equipment evaluation/selection, scale up and process validation
• Knowledge of solid‑state properties, polymorphism, and crystallization principles relevant to small‑molecule drug substance
• Extensive third‑party drug substance CDMO management experience including tech transfer activities, QbD and DoE studies, clinical supply production, registration batch production and commercial launch activities
• In‑depth knowledge of relevant cGMP, ICH, FDA and EMA guidelines
• Proven track record of effective internal and external collaboration
• Excellent oral and written communication skills, interpersonal skills and problem‑solving abilities
• Ability to multi‑task, manage conflict and work in a fast‑paced environment
• Ability to travel up to 25% of their time

Responsibilities

• Provide engineering leadership to design, develop and optimize scalable routes for small‑molecule DS manufacturing.
• Review equipment configurations, qualification packages, and maintenance records at CDMOs to ensure optimal performance.
• Oversee equipment engineering and scale‑up operations at DS CDMOs, including hands‑on process troubleshooting.
• Lead technology transfer to CDMOs including scale‑up and demonstration of new chemical processes in development and commercial equipment.
• Coordinate with CDMOs and Nurix Quality Assurance, and Global Supply Chain functions to ensure timely manufacture and release of DS lots.
• Partner within Nurix CMC to drive process understanding using engineering principles, DoE and QbD concepts.
• Review and approve Master Batch Records, campaign reports, deviation investigations and change controls for drug substance operations.
• Ensure manufacturing operations adhere to company quality, safety and regulatory standards (FDA, EMA, ICH, cGMP).
• Provide regular Person‑In‑Plant support for DS manufacturing and KPI monitoring across sites.
• Author and review CMC sections of regulatory filings including INDs/IMPD, and NDA/MAA.
• Define and drive long‑term engineering strategy for bexobrutideg DS, including lifecycle management and cost‑of‑goods optimization.
• Represent Chemical Engineering on CMC and cross‑functional program teams.
• Manage and provide technical mentorship of scientists and engineers.

Skills

GMP experience

Process development

Scale-up

Tech transfer

CDMO management

DoE

QbD

Regulatory knowledge

cGMP knowledge

Cross-functional collaboration

Education

Ph.D. in chemical engineering

Job description

Nurix Therapeutics is seeking an Associate Director, Chemical Engineering to lead end-to-end chemical engineering support for bexobrutideg DS from late-stage development through commercial launch, including CDMO oversight and tech transfer.

Reporting to the Director, Chemical Development, you will drive scalable routes, supervise CDMO operations, ensure cGMP compliance, and collaborate across CMC, QA, and supply chain to support timely manufacturing and regulatory readiness.