Assoc Director, Quantitative Clinical Pharmacology & MIDD

Scorpion Therapeutics; Boston (MA); On-site; USD 250,000 - 360,000; Full time

Benefits offered by this job

Medical/dental/vision benefits

401(k) with match

Disability insurance

Life insurance

Tuition reimbursement

Volunteer time off

Paid vacation

Job summary

Scorpion Therapeutics in Boston seeks a Global/regional Clinical Pharmacology Lead to define dose selection strategies across multiple programs from pre-FIH through life-cycle management and to enable MIDD.

You will integrate PK/PD, efficacy, and safety data, lead regulatory interactions, mentor staff, and collaborate with pharmacometrics, statistics, DMPK, and discovery teams to advance development.

Qualifications

• PharmD or PhD with 5+ years in a quantitative field with exposure to clinical pharmacology/PK-PD.
• MS with 8+ years in a quantitative field with exposure to clinical pharmacology/PK-PD.

Responsibilities

• Lead strategic, scientific, and operational aspects of multiple drug development projects with independence; primary responsibility for dosage selection and generation of causality evidence.
• Integrate pharmacokinetic, pharmacodynamic, efficacy, and safety data from multiple sources to optimize dosing for different populations.
• Draft and execute clinical pharmacology plans, integrating M&S, in collaboration with pharmacometrics, statistics, and DMPK.
• Enable MIDD practices and modeling/simulation approaches (e.g., QSP, MBMA) for internal decisions and regulatory interactions.
• Represent Clinical Pharmacology in meetings with global/regional regulatory agencies; prepare clinical pharmacology summary documents for regulatory submissions.
• Oversee and/or independently perform PK, PD, and pharmacometric analyses; interpret PK/PD data with DSI and external partners.
• Maintain good clinical practice, compliance, and ethics; mentor junior staff.
• Participate in Business Development due diligence (when requested) and contribute to infrastructure/cross-functional best practices.

Skills

Clinical pharmacology

PK/PD modeling

Dose selection

Regulatory knowledge

Cross-functional collaboration

Education

PharmD/PhD with 5+ years

MS with 8+ years

Tools

DMPK

Pharmacometrics

MBMA

QSP

Job description

Scorpion Therapeutics in Boston seeks a Global/regional Clinical Pharmacology Lead to define dose selection strategies across multiple programs from pre-FIH through life-cycle management and to enable MIDD.

You will integrate PK/PD, efficacy, and safety data, lead regulatory interactions, mentor staff, and collaborate with pharmacometrics, statistics, DMPK, and discovery teams to advance development.