Assay Development Scientist – Small Molecule Discovery

Advanced Clinical; Alameda (CA); On-site; USD 90,000 - 120,000; Full time

Benefits offered by this job

Health coverage

Life insurance

Disability insurance

401k benefits

Job summary

Advanced Clinical is seeking a Research Associate to support early-stage small molecule discovery by developing, optimizing, and executing biochemical and biophysical assays. This role contributes to hit identification, validation, mechanism-of-action studies, and lead optimization through robust assay platforms and HTS activities.

The ideal candidate has hands-on assay development, screening technologies, and laboratory automation experience in a fast-paced discovery environment, with strong

Qualifications

• Bachelor's degree in a scientific discipline with 5+ years of relevant experience; Associate degree with 7+ years of experience.
• Hands-on experience with biochemical and biophysical assay development for small molecule research.
• Experience developing and executing high-throughput screening assays and screening campaigns.
• Experience working with microplate-based assay formats and compound profiling workflows.
• Strong data analysis, problem-solving, and scientific interpretation skills.
• Excellent written and verbal communication skills.
• Ability to manage multiple priorities and work effectively in a collaborative research environment.

Responsibilities

• Develop, optimize, and execute biochemical and biophysical assays to support small molecule discovery programs.
• Design and perform high-throughput screening (HTS) campaigns and compound profiling studies.
• Develop assays to support hit identification, hit validation, mechanism-of-action investigations, and lead optimization activities.
• Evaluate and implement new technologies, workflows, and laboratory methods to improve screening and assay performance.
• Analyze, interpret, and communicate experimental results to project teams and stakeholders.
• Prepare technical reports, presentations, and maintain accurate laboratory documentation.
• Collaborate with cross-functional research teams to support project objectives and timelines.
• Follow laboratory safety procedures and maintain compliance with established research practices.

Skills

Data analysis

Problem solving

Communication

Collaboration

Prioritization

Independent work

Education

Bachelor's degree in science

Associate degree with 7+ years experience

Tools

SPR

BLI

MST

HSR/HTRF/ELISA/MSD

AlphaLISA

Laboratory automation

Job description

Advanced Clinical is seeking a Research Associate to support early-stage small molecule discovery by developing, optimizing, and executing biochemical and biophysical assays. This role contributes to hit identification, validation, mechanism-of-action studies, and lead optimization through robust assay platforms and HTS activities.

The ideal candidate has hands-on assay development, screening technologies, and laboratory automation experience in a fast-paced discovery environment, with strong