Applications Lab Associate II

Twistbioscience; South San Francisco (CA); On-site; USD 116,000 - 135,000; Full time

Benefits offered by this job

Bonus

Equity

Benefits package

Job summary

Twist Bioscience based in the San Francisco Bay Area seeks a detail-oriented scientist to support customer-driven NGS projects in a fast-paced service lab. You will collaborate with Sales, R&D, Field Applications, and Customer Support to deliver high-quality sequencing data and solutions.

The role emphasizes hands-on molecular biology, library preparation, data interpretation, and rigorous documentation in a regulated environment. Timeliness and teamwork are essential to success.

Qualifications

• BS/MS in Molecular Biology, Biochemistry, Chemistry or related field; associates considered with relevant experience.
• Hands-on molecular biology techniques including PCR/qPCR, DNA quantification, library prep.
• Strong attention to detail and meticulous documentation practices.

Responsibilities

• Execute NGS library preparation, target enrichment, and sequencing workflows.
• Process samples to meet production schedules and customer timelines.
• Perform PCR/qPCR, DNA quantification, purification, and electrophoresis as needed.
• Operate and maintain lab equipment, incl. liquid handling robots and sequencers.
• Troubleshoot issues to maintain workflow continuity and data quality.
• Track and document projects and batch records with deviations.
• Analyze data and contribute to result interpretation.
• Develop and optimize NGS protocols and workflows.

Skills

Molecular biology techniques

PCR/qPCR

NGS library prep

Documentation practices

Cross-functional collaboration

Education

BS/MS in Molecular Biology

Tools

BioAnalyzer

TapeStation

Qubit

Nanodrop

Job description

Twist Bioscience is seeking a highly motivated and detail-oriented individual to support customer-driven Next Generation Sequencing (NGS) projects within a fast-paced, service laboratory. This role will work cross-functionally with Sales, R&D, Field Applications, and Customer Support teams to deliver high-quality sequencing data and solutions. The ideal candidate thrives in a dynamic environment, is highly organized, and is committed to maintaining production timelines while ensuring scientific excellence.

What You'll Be Doing

• Execute NGS library preparation, target enrichment, and sequencing workflows according to established protocols
• Process samples for NGS analysis while meeting production schedules and customer timelines
• Perform routine molecular biology techniques including PCR/qPCR, DNA quantification, purification (e.g., SPRI), and electrophoresis
• Operate and maintain laboratory equipment, including liquid handling robots and sequencing platforms
• Troubleshoot experimental and equipment-related issues to ensure continuity of workflows
• Track multiple projects and samples simultaneously, ensuring accurate and detailed documentation (including batch records and deviations)
• Analyze experimental data and contribute to interpretation of results
• Support development, optimization, and execution of NGS-related protocols and workflows
• Maintain digital files and records associated with sequencing runs
• Ensure compliance with regulatory standards (e.g., ISO 13485) and internal quality requirements
• Support general lab operations including cleaning, restocking, and maintaining a well-organized workspace
• Collaborate effectively with cross-functional teams under aggressive timelines

What You'll Bring to the Team

• B.S. or M.S. in Molecular Biology, Biochemistry, Chemistry, or a related field (Associates degree with relevant experience may be considered)
• Hands-on experience in molecular biology techniques such as PCR, DNA purification, quantification, and library preparation
• Experience working in a laboratory environment with strong attention to detail and documentation practices
• Ability to manage multiple tasks and prioritize effectively in a fast-paced environment
• Strong organizational, planning, and problem-solving skills
• Excellent interpersonal and communication skills with a collaborative mindset
• Self-motivated with a commitment to delivering high-quality results

Preferred Qualifications

• 3-5 years of experience in molecular biology, NGS workflows, or a related field
• Direct experience with NGS platforms (e.g., Illumina, PacBio, Element, ONT) and associated sample preparation workflows
• Experience with NGS library preparation and target enrichment workflows
• Experience with a range of NGS applications DNA, RNA, and Methylation assays
• Strong familiarity with analytical tools such as BioAnalyzer or TapeStation, Qubit fluorometry and Nanodrop spectrophotometry

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.

San Francisco Bay Area Pay Range

$116,000-$135,000 USD