Analytical Science and Technology Senior Scientist

Vertex Pharmaceuticals Inc (US); Boston (MA); Hybrid; USD 120,000 - 180,000; Full time

Benefits offered by this job

Medical, dental and vision benefits

Generous paid time off

Educational assistance programs

Job summary

Vertex Pharmaceuticals Inc. is seeking a Senior Scientist in Analytical Sciences & Technology (AS&T) to support launch readiness and lifecycle management for the commercial CGT portfolio.

You will provide expertise in biological assays and analytical requirements, guiding method development, validation, and lifecycle management to ensure robust performance and compliance. The role emphasizes collaboration with Analytical Development, Process Development, Commercial Manufacturing, Quality, and

Qualifications

• Experience with analytical method development and validation for biologics or CGT products.
• Strong knowledge of GMP, regulatory guidelines (ICH/USP/EMA).
• Experience managing external analytical testing (CTO/CDMO) is a plus.
• Proven ability to support commercial biologics with cGMP manufacturing.
• Excellent writing and communication skills for technical docs.

Responsibilities

• Own the success of commercial analytical activities, prioritization, and execution.
• Serve as SME for analytical methods and commercial testing requirements.
• Author/review method SOPs, study protocols, and technical reports.
• Collaborate with internal and external functions for tech transfer.
• Oversee analytical testing at CDMOs and contract labs.

Skills

Analytical method development

cGMP manufacturing

ICH/USP/EMA knowledge

Cross-functional collaboration

Technical writing

Education

Bachelor’s degree or above in Science or related discipline

Job description

Job Description General Summary: The Senior Scientist, Analytical Sciences & Technology (AS&T), plays a critical role in the Commercial Manufacturing & Supply Chain team. You will be responsible for providing strong expertise with biological assays and analytical requirements to ensure launch readiness and lifecycle management for the commercial Cell and Gene therapy (CGT) portfolio.

Key Duties and Responsibilities

• Accountable for the success of commercial analytical activities, prioritization, and execution to meet program commitments
• Subject Matter Expertise (SME) for ensuring the robustness of analytical methods and commercial testing requirements
• Author and/or review technical documents, including method SOP, study protocol and technical report
• Partners effectively with internal and external functions for commercial analytical technology transfer
• Primary responsibilities extend to analytical method validations, continuous improvement, and lifecycle management
• Collaborate with Vertex cross-functions, including Analytical Development, Process Development, Commercial Manufacturing, Supply Chain, Quality teams, Vertex Partners, and Contract Test labs.
• Provides oversight for analytical testing and method performance executed at CDMOs and contract testing labs

Knowledge and Skills

• Demonstrated expertise in analytical method development, characterization, and qualification/validation for biologics
• Knowledgeable in ICH/USP/EMA guidelines with a strong GMP background, CGT related preferred
• Experience managing contract (CTO/CDMO) analytical testing, highly desirable
• Experience with technical support of commercial biological products and cGMP manufacturing
• Ability to prioritize objectives from multiple projects and adhere to scheduled timelines while maintaining flexibility and efficiency
• Excellent technical writing skills, and communication skills with the proven ability to build open and collaborative
• Hands-on experience with methods related to CGT products, prefer in-vitro cell-based functional, potency and/or microbiology assays

Education and Experience

• Bachelor’s degree or above in Science or related discipline
• 6 years of experience in the pharmaceutical/biopharmaceutical industry with increasing project the equivalent combination of education and experience

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range: $120,000 - $180,000

Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

Benefits

• From medical, dental and vision benefits
• Generous paid time off (including a week-long company shutdown in the Summer and the Winter)
• Educational assistance programs including student loan repayment
• A generous commuting subsidy
• Matching charitable donations
• 401(k)
• And so much more

Flex Designation

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status

In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.

Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]

Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.

Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For.

For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X

We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.