Analytical Development Research Scientist

Vertex Pharmaceuticals Inc (US); Boston (MA); On-site; USD 103,000 - 154,000; Full time

Job summary

Vertex is seeking an Analytical Development professional in Boston, MA to conduct analytical chemistry activities for small molecule programs. Responsibilities include testing, data review, method validation support, and cross-functional collaboration to address development challenges.

Ideal candidates have strong LC/HPLC skills, GMP understanding, and a track record in analytical development within pharma. This on-site role offers a competitive salary and bonus potential in a dynamic team.

Qualifications

• BS/MS/PhD in life or physical sciences with preference for analytical chemistry.
• Experience with analytical development and method validation preferred.
• Understanding of GMP and regulatory guidelines is advantageous.

Responsibilities

• Perform analytical testing and review data to support project decisions.
• Independently design and execute challenging experiments with reliability and attention to detail.
• Support method validation and cross-functional team projects in drug development.

Skills

Analytical testing

Data interpretation

LC/HPLC

GMP knowledge

Cross-functional collaboration

Problem solving

Lab techniques

Education

BS/MS/PhD in life or physical sciences

Tools

LC/GC/KF

Job description

Job Description General Summary:

Vertex is seeking a talented individual to join our Analytical Development group in Boston, MA. As a member of an industry leading CMC team, this individual will help advance transformative medicines treating the underlying cause of serious diseases by conducting analytical chemistry activities for small molecule development programs. Responsibilities include characterization and stability assessment of drug substances, spray-dried dispersions, and drug products, as well as contributing scientifically to the resolution of broader drug development challenges in collaboration with other R&D functions. Expertise with laboratory techniques commonly used in the analysis of pharmaceutical products, including liquid chromatography (LC), is desired.

Key Duties and Responsibilities:

Analytical testing and data review, as well as collation, interpretation, and presentation of complex data along with recommendations to guide project decisions and new research activities Independently designing and performing technically challenging experiments in a resourceful manner with a high degree of reliability and attention to details Solving complex problems to support crucial project goals, as well as innovation of research methodology to address important questions enabling the advancement of development programs Supporting method validation activities, including designing validation protocols that follow ICH and FDA guidelines and address critical factors that may not be mandated by the guidelines but are essential for validating the methods for their intended use Representing Analytical Development on cross functional pharmaceutical development teams Prioritizing studies, considering feasibility, timelines, and project impact Troubleshooting and maintain general lab equipment, including LCs Maintaining accurate records of experiments and results in an electronic laboratory notebook in a timely manner Working collaboratively cross-functionally and within the team to achieve program goals Complying with applicable SOPs May supervise or mentor junior staff

Knowledge and Skills:

Understanding of the drug development process, including chemical and formulation development Skilled in HPLC, GC, KF, and broad knowledge of other techniques used in pharmaceutical analysis Good understanding of GMP is preferred. Hands-on GMP experience, as well as experience developing GMP friendly methods is a plus The ability to work successfully in both a team/matrix environment as well as independently is required The ability to work in a fast-paced environment, manage priorities, and maintain timelines for multiple activities are required Excellent written and verbal communication skills are essential

Education and Experience:

A BS, Master’s degree or Ph.D. in the life or physical sciences with a preference for a concentration in analytical chemistry Minimum experience: Ph.D. with 0-3 years or MS with 3+ years or BS with 6+ years of relevant analytical development experience At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$102,800 - $154,200 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

Flex Designation:

On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.