Analytical Development Scientist, Biologics & CGT

Vertex Pharmaceuticals; Boston (MA); On-site; USD 83,000 - 85,000; Full time

Job summary

Vertex Pharmaceuticals in Boston is seeking a Scientist, Analytical Development to support analytical strategy and method development for complex therapeutic programs, with emphasis on biologics and cell and gene therapy.

This role focuses on developing, optimizing, qualifying, and transferring analytical methods to characterize product quality, purity, identity, and stability, using HPLC, LC-MS, and biophysical techniques.

Qualifications

• Bachelor’s, Master’s, or PhD in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, Molecular Biology, or a related scientific discipline
• Experience in analytical development and pharmaceutical/biotech development
• Strong hands-on experience with HPLC/UPLC and LC-MS
• Experience with biophysical characterization techniques (DLS, SEC-MALS, CE) is a plus
• Excellent data interpretation and cross-functional communication

Responsibilities

• Develop, qualify, and transfer analytical methods for characterization of therapeutic materials, intermediates, and final products
• Apply and troubleshoot analytical techniques including HPLC/UPLC, LC-MS, DLS, SEC-MALS, and CE
• Perform biophysical characterization to assess quality attributes such as purity, aggregation, size distribution, molecular weight
• Generate, analyze, interpret, and communicate analytical data to cross-functional teams
• Maintain documentation and support ELN usage

Skills

Analytical Chemistry

Biochemistry

Molecular Biology

Education

Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, Molecular Biology (degree)

Tools

HPLC/UPLC

LC-MS

DLS

SEC-MALS

CE

Job description

Vertex Pharmaceuticals in Boston is seeking a Scientist, Analytical Development to support analytical strategy and method development for complex therapeutic programs, with emphasis on biologics and cell and gene therapy.

This role focuses on developing, optimizing, qualifying, and transferring analytical methods to characterize product quality, purity, identity, and stability, using HPLC, LC-MS, and biophysical techniques.