Analytical Chemistry Lead — Drug Discovery

IDEAYA Biosciences; South San Francisco (CA); On-site; USD 167,000 - 206,000; Full time

Job summary

IDEAYA Biosciences in South San Francisco is seeking a Principal Research Scientist, Analytical Chemistry to oversee discovery analytical work on site four days per week. You will collaborate with medicinal chemistry and cross-functional teams to drive drug discovery pipeline goals and ensure analytical rigor.

The role requires a Ph.D. in analytical chemistry with 5+ years in drug discovery, expertise in HPLC/SFC, method development, and CRO oversight.

Qualifications

• Ph.D. in analytical chemistry or related field with 5+ years in drug discovery.
• Expertise in HPLC and SFC purification.
• Analytical method development/validation and CRO management.
• Ability to mentor junior scientists and work in cross-functional teams.

Responsibilities

• Oversee small molecule analytical chemistry efforts across the IDEAYA discovery portfolio.
• Manage and execute compound purifications (including chiral SFC separations), structural elucidations, biophysical property determinations (solubility, logD, pKa) and stability studies.
• Manage junior analytical chemist(s) to achieve strong productivity with high quality and scientific rigor.
• Ensure existing methods are technically sound, well developed and fit-for-purpose.
• Troubleshoot methods and provide technical guidance across discovery programs.
• Manage installation and maintenance of lab analytical equipment.
• Perform vendor review and selection and provide oversight of all analytical work at external CROs.
• Proactively communicate with and work closely with other functions to align analytical strategy and goals.
• Help hire high-caliber analytical chemists to build a world-class department.
• Stay aware of emerging techniques and bring new capabilities online as necessary.

Job description

IDEAYA Biosciences in South San Francisco is seeking a Principal Research Scientist, Analytical Chemistry to oversee discovery analytical work on site four days per week. You will collaborate with medicinal chemistry and cross-functional teams to drive drug discovery pipeline goals and ensure analytical rigor.

The role requires a Ph.D. in analytical chemistry with 5+ years in drug discovery, expertise in HPLC/SFC, method development, and CRO oversight.