AI-Driven DMPK & Modeling Director, AIRx

Takeda Pharmaceutical Company Limited; Boston (MA); On-site; USD 212,000 - 333,000; Full time

Job summary

Takeda Pharmaceutical Company Limited in Boston, MA seeks an AIRx DMPK & Modeling Lead to shape quantitative DMPK strategy across ADME, PK/PD, and QSP, guiding program decisions with AI-enabled DMTA cycles. You will oversee CRO-based DMPK work, ensuring data quality and interpretability to speed clinical progression.

A PhD with 12–15+ years in pharmaceutical DMPK and modeling is required, with experience contributing to IND-enabling packages and translating preclinical data into clinical

Qualifications

• PhD in a relevant scientific discipline with 12–15+ years of industry experience in DMPK and modeling.
• Proven contributions to IND filings; experience supporting IND-enabling DMPK packages.
• Experience designing and managing external CRO DMPK programs; ability to scope, oversee, and critically interpret study data.
• Ability to connect DMPK to clinical hypothesis and translational strategy.
• AI/ML data integration experience; comfortable working with large multi-source datasets.

Responsibilities

• Portfolio-level impact across AIRx programs.
• Owns the DMPK, PK/PD, and modeling strategy across the AIRx portfolio; drive model-informed decisions.
• Embed DMPK & modeling into AI-enabled DMTA cycles, integrating in vitro/in vivo ADME data, PK, PBPK, and mechanistic (QSP) models; AI/ML predictions.
• Design and oversee CRO-based DMPK and modeling activities with speed and rigor; ensure high-quality, interpretable data packages.
• Challenge scientific assumptions across the team; ensure DMPK integrity and mechanistic depth underpin all program decisions.
• Represent DMPK perspectives at Takeda governance forums; contribute to IND-enabling packages.

Skills

ADME

PK/PD

Mechanistic modeling

AI/ML data integration

Cross-functional leadership

DMPK strategy

Education

PhD in a relevant scientific discipline with 12-15+ years of industry experience in pharmaceutical DMPK and modeling

Job description

Takeda Pharmaceutical Company Limited in Boston, MA seeks an AIRx DMPK & Modeling Lead to shape quantitative DMPK strategy across ADME, PK/PD, and QSP, guiding program decisions with AI-enabled DMTA cycles. You will oversee CRO-based DMPK work, ensuring data quality and interpretability to speed clinical progression.

A PhD with 12–15+ years in pharmaceutical DMPK and modeling is required, with experience contributing to IND-enabling packages and translating preclinical data into clinical